Successful ceritinib treatment in a man with MPE and an ALK fusion gene mutation after multiple treatments

Wei, Hangping; Du, Fangming; Lu, Y.; Wei, Juan; Dong, Xiaofang

doi:10.1186/s40064-016-3674-3

Cited by 3 publications

(2 citation statements)

References 18 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therapy could be targeted on an oncogene coming from a fusion of two genes: EML 4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), and inhibitors of its activity - crizotinib or ceritinib [143]. There have been reports of success in the treatment of MPE with these drugs in patients in whom other treatments have been found to be ineffective [144]. Sun et al reported a woman with a locally advanced adenocarcinoma of the lung and a bloody pleural effusion treated with a drainage (approximately 1000 ml/day) that did not respond to chemotherapy.…”

Section: Potential New Treatment Options For Mpementioning

confidence: 99%

Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration

et al. 2019

View full text Add to dashboard Cite

Chemical pleurodesis is a therapeutic procedure applied to create the symphysis between the parietal and visceral pleura by intrapleural administration of various chemical agents (e.g. talk, tetracycline, iodopovidone, etc.). The two major clinical conditions treated with chemical pleurodesis are recurrent pleural effusion (PE) and recurrent spontaneous pneumothorax. Although the history of chemical pleurodesis began over a century ago, detailed data on the mechanisms of action of sclerosing agents are highly incomplete. The following article aims to present the state of knowledge on this subject.It is believed that mesothelial cells are the main structural axis of pleurodesis. In response to sclerosing agents they secrete a variety of mediators including chemokines such as interleukin 8 (IL-8) and monocyte chemoattractant protein (MCP-1), as well as growth factors - vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and transforming growth factor- β (TGF-β). Numerous data suggest that intact mesothelial cells and the above cytokines play a crucial role in the initiation and maintenance of different pathways of pleural inflammation and pleural space obliteration.It seems that the process of pleurodesis is largely nonspecific to the sclerosant and involves the same ultimate pathways including activation of pleural cells, coagulation cascade, fibrin chain formation, fibroblast proliferation and production of collagen and extracellular matrix components. Of these processes, the coagulation cascade with decreased fibrinolytic activity and increased fibrinogenesis probably plays a pivotal role, at least during the early response to sclerosant administration.A better understanding of various pathways involved in pleurodesis may be a prerequisite for more effective and safe use of various sclerosants and for the development of new, perhaps more personalized therapeutic approaches.

show abstract

Section: Potential New Treatment Options For Mpementioning

confidence: 99%

Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Crizotinib and ceritinib are oral inhibitors of anaplastic lymphoma kinase (ALK), and they have been approved for the treatment of advanced cancer or metastatic NSCLC [59,60]. Only in some cases, it has been observed QTc prolongation, and therefore this anomaly is not frequent.…”

Section: Crizotinib and Ceritinibmentioning

confidence: 99%

Management of QT prolongation induced by anti-cancer drugs: Target therapy and old agents. Different algorithms for different drugs

Coppola

Rienzo

Piscopo

et al. 2018

Cancer Treatment Reviews

View full text Add to dashboard Cite

The side effects of anticancer drugs still play a critical role in survival and quality of life. Although the recent progresses of cancer therapies have significantly improved the prognosis of oncologic patients, side effects of antineoplastic treatments are still responsible for the increased mortality of cancer survivors. Cardiovascular toxicity is the most dangerous adverse effect induced by anticancer therapies. A survey conducted by the National Health and Nutrition Examination, showed that 1807 cancer survivors followed up for seven years: 51% died of cancer and 33% of heart disease (Vejpongsa and Yeh, 2014). Moreover, the risk of cardiotoxicity persists even with the targeted therapy, the newer type of cancer treatment, due to the presence of on-target and off-target effects related to this new class of drugs. The potential cardiovascular toxicity of anticancer agents includes: QT prolongation, arrhythmias, myocardial ischemia, stroke, hypertension (HTN), thromboembolism, left ventricular dysfunction and heart failure (HF). Compared to other cardiovascular disorders, the interest in QT prolongation and its complications is fairly recent. However, oncologists have to deal with it and to evaluate the risk-benefit ratio before starting the treatment or during the same. Electrolyte abnormalities, low levels of serum potassium and several drugs may favour the acquired QT prolongation. Treatment of marked QT prolongation includes cardiac monitoring, caution in the use or suspension of cancer drugs and correction of electrolyte abnormalities (hypokalaemia, hypomagnesaemia, hypocalcaemia). Syndrome of QT prolongation can be associated with potentially fatal cardiac arrhythmias and its treatment consists of intravenous administration of magnesium sulphate and the use of electrical cardioversion.

show abstract

Management of QT Prolongation Induced by Anticancer Drugs

Maurea

Paciello

Coppola

et al. 2018

Cardiovascular Complications in Cancer Therapy

View full text Add to dashboard Cite

Successful ceritinib treatment in a man with MPE and an ALK fusion gene mutation after multiple treatments

Cited by 3 publications

References 18 publications

Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration

Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration

Management of QT prolongation induced by anti-cancer drugs: Target therapy and old agents. Different algorithms for different drugs

Management of QT Prolongation Induced by Anticancer Drugs

Contact Info

Product

Resources

About