Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flow

Pearce, F. Bennett; Kirklin, James K.; Holman, William L.; Barrett, Cindy; Romp, Robb L.; Lau, Yung R.

doi:10.1016/j.jtcvs.2008.02.044

Cited by 38 publications

(33 citation statements)

References 5 publications

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“…VAD support was maintained for 7 weeks before successful transplant was performed. 23 Previous to our report, the largest review of SV patients treated with a VAD was by Van der Pluym and colleagues 26 ; this review comprised 10 patients treated since 1988 with 4 different forms of support.…”

Section: Discussionmentioning

confidence: 97%

“…6,19 Children with SV treated with mechanical assistance represent an even smaller subset of patients, and the literature on this experience is largely limited to single-center case reports. 5,6,[20][21][22][23][24][25] Use of VAD support in a patient with a single ventricle was first reported in 2005 in an 25-yearold man after a Fontan operation. The patient was supported for 5 months before successful orthotopic heart transplantation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The use of the Berlin Heart EXCOR in patients with functional single ventricle

Weinstein

Bello

Pizarro

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

199

174

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The use of the Berlin Heart EXCOR in patients with functional single ventricle

Weinstein

Bello

Pizarro

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

199

174

View full text Add to dashboard Cite

show abstract

“…A report of North American EXCOR Pediatric patients included 19 single-ventricle patients; no data beyond mortality is reported (2). Other published reports are limited to case reports (3)(4)(5)(6)(7)(8)(9)(10). We present a series of four patients with single-ventricle heart disease palliated with superior cavopulmonary anastomosis (SCPA) supported by the EXCOR Pediatric.…”

mentioning

confidence: 99%

Ventricular Assist Device in Single‐Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis

et al. 2015

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Our objective is to describe the use of a ventricular assist device (VAD) in single-ventricle patients with circulatory failure following superior cavopulmonary anastomosis (SCPA). We performed a retrospective chart review of all single-ventricle patients supported with a VAD following SCPA. Implantation techniques, physiologic parameters while supported, medical and surgical interventions postimplant, and outcomes were reviewed. Four patients were supported with an EXCOR Pediatric (Berlin Heart Inc., The Woodlands, TX, USA) following SCPA for a median duration of 10.5 days (range 9-312 days). Selective excision of trabeculae and chords facilitated apical cannulation in all patients without inflow obstruction. There were two pump exchanges in the one patient supported for 312 days. Two patients were evaluated by cardiac catheterization while supported. Three of four patients were successfully bridged to transplantation. One patient died while supported. All patients had significant bleeding at the time of transplantation, and one required posttransplant extracorporeal membrane oxygenation with subsequent full recovery. VAD support can provide a successful bridge to transplantation in patients with single-ventricle circulation following SCPA. A thorough understanding of the challenges encountered during this support is necessary for successful outcomes.

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“…These include the Berlin Heart EXCOR (EXCOR) (Berlin Heart, GmbH, Berlin, Germany), the HeartMate II (HMII) [ (4,9,11,(36)(37)(38). The EXCOR is an extracorporeal pneumatically driven pulsatile device with a large controller tower.…”

Section: Device Typementioning

confidence: 99%

An overview of mechanical circulatory support in single-ventricle patients

et al. 2018

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The population of people with a single-ventricle is continually increasing due to improvements across the spectrum of medical care. Unfortunately, a proportion of these patients will develop heart failure.Often, for these patients, mechanical circulatory support (MCS) represents the only available treatment option. While single-ventricle patients currently represent a small proportion of the total number of patients who receive MCS, as the single-ventricle patient population increases, this number will increase as well.Outcomes for these complex single-ventricle patients who require MCS has begun to be evaluated. When considering the entire population, survival to hospital discharge is 30-50%, though this must be considered with the significant heterogeneity of the single-ventricle patient population. Patients with a single-ventricle have unique anatomy, mechanisms of failure, indications for MCS and the type of support utilized. This has made the interpretation and the generalizability of the limited available data difficult. It is likely that some subsets will have a significantly worse prognosis and others a better one. Unfortunately, with these limited data, indications of a favorable or poor outcome have not yet been elucidated. Though currently, a database has been constructed to address this issue. While the outcomes for these complex patients is unclear, at least in some situations, they are poor. However, significant advances may provide improvements going forward, including new devices, computer simulations and 3D printed models. The most important factor, however, will be the increased experience gained by the heart failure team to improve patient selection, timing, device and configuration selection and operative approach.

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Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flow

Cited by 38 publications

References 5 publications

The use of the Berlin Heart EXCOR in patients with functional single ventricle

The use of the Berlin Heart EXCOR in patients with functional single ventricle

Ventricular Assist Device in Single‐Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis

An overview of mechanical circulatory support in single-ventricle patients

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