“…Systemic HBOT has already been established as an adjunctive treatment to composite grafts for improving and supporting ischemic wounds [ 1 , 2 ], and Thom [ 3 ] described the mechanism of HBOT, reporting that HBOT increased cellular oxygen levels, which, in turn, increased the generation of reactive oxygen species and reactive nitrogen species, which served as signaling molecules in both angiogenesis and protection of ischemia-reperfusion injury pathways. Furthermore, based on these findings regarding HBOT, studies on local HBOT also have been conducted in animal models, and reports showing its efficacy have been published [ 4 , 5 ].…”