Successful ambulatory treatment of Hodgkin's disease in Iranian children based on German-Austrian DAL-HD 85-90: single institutional results

Abstract

The DAL/GPOH-HD-based treatment approach proved to achieve long-term sustained cure even in children with advanced HD disease. The essentially outpatient diagnosis and treatment modus did not compromise the disease outcome, and was well tolerated and accepted by the patients and their parents. The employed drugs are easily available and affordable. This treatment approach is suitable for ambulatory use in developing countries. However, male infertility remains the major obstacle to procarbazine and cyclophosphamide use.

Developing anticancer chemotherapy services in a developing country: Hodgkin lymphoma experience

“…The delay in referral is also supported by the fact that most patients (83%) had advanced disease (≥clinical stage IIb) at diagnosis. Similar observations have been made in earlier studies from India and other developing countries with advanced disease being present at diagnosis in 55–70% cases 5–8. Another significant observation is the very high male to female ratio of 10.5:1.…”

A chemotherapy only therapeutic approach to pediatric Hodgkin lymphoma: AHOPCA LH 1999

“…The proportion of patients with mixed cellularity histology in our current report (35.2%) was higher than that seen in the pediatric oncology group reports of 19% and 8.9% ( P < 0.0001). However, it was lower than that reported from LIC, including our previous report that varied from 52% to 86% ( P < 0.0001). It was unclear whether these differences were due to the histology of HL changed by improved economic status in Central America causing a change in the biology of HL and/or whether more rigorous criteria and greater experience with histological classification led to better recognition of nodular sclerosis histology.…”

Hodgkin lymphoma in very young children: Clinical characteristics and outcome of treatment

“…The treatment outcome for our patients is somewhat lower than that reported for patients in developed countries; however they are comparable with results from other developing countries [20,21]. Using a similar treatment strategy, Hsu et al have shown a significant difference in the outcome of children treated in a low income country compared with centers in the US [22].…”