Successes and Failures of Bacteriophage Treatment of Enterobacteriaceae Infections in the Gastrointestinal Tract of Domestic Animals

Bielke, Lisa R.; Téllez, G.; Hargis, Billy M.

doi:10.5772/33407

Cited by 3 publications

(7 citation statements)

References 73 publications

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“…Taking into account the above assumptions, special attention has been paid to the possibility of rectal application of a phage suspension in order to bypass gastric juice and rumen microflora (Bielke et al, 2012). Research by Sheng et al (2006) based on previous in vitro experiments (Naylor et al, 2003) has shown that application of a KH1 and SH1 phage cocktail (10 10 PFU mL −1 ) to young beef cattle in the form of a suspension per rectum with simultaneous administration of the same lytic phages (10 6 PFU mL −1 ) with drinking water caused a significant reduction in Shiga toxin-producing strains of E. coli O157:H7 in experimentally infected calves up to the detectable limit in most of the calves.…”

Section: Experimental Phage Therapy In Ruminantsmentioning

confidence: 99%

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Efficacy of experimental phage therapies in livestock

Dec

Wernicki

Urban‐Chmiel

2020

Anim. Health. Res. Rev.

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Bacteriophages are the most abundant form of life on earth and are present everywhere. The total number of bacteriophages has been estimated to be 1032 virions. The main division of bacteriophages is based on the type of nucleic acid (DNA or RNA) and on the structure of the capsid. Due to the significant increase in the number of multi-drug-resistant bacteria, bacteriophages could be a useful tool as an alternative to antibiotics in experimental therapies to prevent and to control bacterial infections in people and animals. The aim of this review was to discuss the history of phage therapy as a replacement for antibiotics, in response to EU regulations prohibiting the use of antibiotics in livestock, and to present current examples and results of experimental phage treatments in comparison to antibiotics. The use of bacteriophages to control human infections has had a high success rate, especially in mixed infections caused mainly by Staphylococcus, Pseudomonas, Enterobacter, and Enterococcus. Bacteriophages have also proven to be an effective tool in experimental treatments for combating diseases in livestock.

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Section: Experimental Phage Therapy In Ruminantsmentioning

confidence: 99%

Section: Phage Experimental Therapies In Animalsmentioning

confidence: 99%

Efficacy of experimental phage therapies in livestock

Dec

Wernicki

Urban‐Chmiel

2020

Anim. Health. Res. Rev.

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“…Faga tersebar luas di ekosistem dan berperanan penting dalam ekologi bakteri. Secara alamiah, faga berada dalam saluran pencernaan manusia, hewan termasuk unggas, pada makanan dan berbagai macam sumber lingkungan seperti sampah, tanah dan air (Bielke et al 2012;Tiwari et al 2014). Faga mampu memelihara keanekaragaman, keseimbangan dan ekologi mikroba dalam saluran pencernaan sapi terutama rumen untuk beradaptasi terhadap perubahan konsumsi pakan dan air minum (Bielke et al 2012).…”

Section: Sumber Bakteriofagaunclassified

“…Secara alamiah, faga berada dalam saluran pencernaan manusia, hewan termasuk unggas, pada makanan dan berbagai macam sumber lingkungan seperti sampah, tanah dan air (Bielke et al 2012;Tiwari et al 2014). Faga mampu memelihara keanekaragaman, keseimbangan dan ekologi mikroba dalam saluran pencernaan sapi terutama rumen untuk beradaptasi terhadap perubahan konsumsi pakan dan air minum (Bielke et al 2012). Faga relatif mudah diisolasi dari berbagai macam sumber termasuk lingkungan yang berasal dari air dilaporkan telah ditemukan beberapa faga yang berbeda famili (Grabow 2001).…”

Section: Sumber Bakteriofagaunclassified

The Use of Bacteriophage for Detection and Biocontrol of Foodborne Pathogen

Ariyanti

2018

WARTAZOA

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Bacteriophages are viruses that have ability to attack bacterial cells in specific receptors, infect, multiply in bacterial cells and eventually lyse bacterial cells. This unique bacteriophage character is highly beneficial because it is harmless to mammalian cells and does not interfere with natural microbes. Bacteriophages are easy to obtain because they are widespread in the environment such as soil, water, animal, and farm waste or food. This paper describes the potential use of bacteriophages to detect pathogen and foodborne pathogen biocontrol. Bacteriophages are very potential to control the growth of pathogenic bacteria both in food industry and environment. Bacteriophages act as antibiotics, detection tool for pathogenic bacteria in the food chain, food biopreservative from pathogen bacteria contamination, and foodborne disease prevention. Although research on bacteriophage in Indonesia has not been widely reported, research on bacteriophage utilization is being carried on.

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“…Moreover, Ahmad et al (2014) isolated CP1 and CP2 bacteriophages that were able to control X. axonopodis pv citri on citrus. Mostly, bacteriophage can be easily isolated from the soil and irrigation water around infected crops (Bielke et al 2012;Kalpage and Costa 2014) and from the symptomatic plant parts (Ritchie and Klos 1977).…”

Section: Introductionmentioning

confidence: 99%

Partial Characterization of Bacteriophages from Indonesia and its Potency as Biocontrol of Xanthomonas oryzae pv. oryzae

Rejeki¹

2021

IJAB

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Bacterial leaf blight (BLB) is a disease caused by Xanthomonas oryzae pv. oryzae (Xoo) of rice in rice-producing countries including Indonesia and attack rice in all stages of growth. In the advanced, crop production will be decreased by up to 50–70%. Recently, the practical efforts to overcome the problem by using resistant varieties, antibiotics, and sanitation; however, the ability of the pathogen to forms the new virulent pathotypes is noteworthy. Alternatively, the pathogen could be environmental-friendly controlled by utilizing bacteriophages as biological control agents because of their specific characteristics to their bacterial hosts. This research aimed to obtain information about the characteristic of the first isolated bacteriophages from Indonesia. The result showed that two bacteriophages had been isolated from soil in Arjasa Jember and soil in Gadingan Situbondo, namely phage XooX1IDN and phage XooX2IDN, respectively. The two phages were inactivated at 80ºC and stable at pH within the range of 6 to 8. The phage XooX1IDN has a genome size of approximately 39 kb, while phage XooX2IDN had a genome size 38 kb. Morphologically, both phages possessed the family of Myoviridae. Phage biocontrol in vitro assay showed that both phages significantly reduced the growth of BLB pathogen, indicating that both phages potentially, as biological control agents for BLB disease in rice. © 2021 Friends Science Publishers

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Successes and Failures of Bacteriophage Treatment of Enterobacteriaceae Infections in the Gastrointestinal Tract of Domestic Animals

Cited by 3 publications

References 73 publications

Efficacy of experimental phage therapies in livestock

Efficacy of experimental phage therapies in livestock

The Use of Bacteriophage for Detection and Biocontrol of Foodborne Pathogen

Partial Characterization of Bacteriophages from Indonesia and its Potency as Biocontrol of Xanthomonas oryzae pv. oryzae

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