Subversion of the Immune Response by Bacterial Pathogens

Immunopathological and Comparative Study of Concanavalin- A and Streptococcus lyophilized Antigen in Immunized Rats

“…The liver tissue manifestation of 3 rd mixed immunized group referred perivascular and periductal Mono Nuclear Cells MNCs infiltration with nuclear pyknosis and the cytoplasm of hepatocyte appear hyper eosinophilic Figure 7A, while another section showed mild periductal Mono Nuclear Cells MNCs infiltration with obvious ductal dilation Figure 7B, as well as evidence of periarteriolar lymphoid hyperplasia were recorded in splenic tissue Figure 7C, accompanied with great lymphoid hyperplasia and red pulp congestion Figure 7D. Streptococci are pathogenic bacteria affect humans and animals cause invasive infection and produced many virulence factors and toxins help escaping the host immune response (Simone et al, 2022) such as M related surface protein as primary antigenic factor have critical role in phagocytic survival and providing antiphagocytic functions also given continuous ability for Streptococcus pyogenes to diversity and variable for that no safe and effective vaccine only slight known about anti-Group A streptococcus pyogenes GAS protective immunity (Douglas et al, 2022).…”