Subungual Syringoid Eccrine Carcinoma of the Great Toe Nail Complex

Grady, John F.; Boumendjel, Yelena; Tahniyath, Maliha S.

doi:10.7547/0003-0538-104.5.504

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…This case occurred in the lateral nail fold of the 15 2006 Angiomatous hamartoma Richardson et al 16 2015 Benign poroma G€ otkay et al 17 2017 Benign poroma Fierro-Arias et al 18 2015 Benign poroma Al-Qattan et al 19 2009 Benign poroma Jayasekera et al 20 2017 Benign poroma Jagdeo et al 21 2006 Benign poroma Yorulmaz et al 22 2020 Benign poroma Moore et al 23 2008 Benign poroma Noh et al 24 2013 Benign poroma Akay et al 25 2020 Hidradenocarcinoma Bhari et al 9 2017 Porocarcinoma Palleschi et al 26 2017 Porocarcinoma van Gorp and van der Putte 10 1993 Porocarcinoma Jarocki et al 27 2020 Porocarcinoma Moussallem et al 28 2008 Porocarcinoma Requena et al 12 1990 Porocarcinoma Sobjanek et al 29 2019 Porocarcinoma Parra-Medina et al 8 2016 Porocarcinoma Ohtsuka et al 30 2002 Spiradenoma Leach and Graham. 31 2004 Spiradenoma Jha et al 32 2016 Spiradenoma Fouilloux et al 33 2001 Syringofibroadenoma Theunis et al 34 2001 Syringofibroadenoma Grady et al 35 2014 Syringoid eccrine carcinoma…”

Section: Hidradenocarcinomamentioning

confidence: 99%

A systematic review of periungual eccrine neoplasms

Rao

Knackstedt

2021

Int J Dermatology

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Eccrine tumors are a rare cutaneous adnexal neoplasm originating from the sweat glands. The periungual region represents an uncommon localization for these neoplasms. We analyzed all published demographic, clinical, and treatment data on periungual eccrine tumors. A systematic review following PRISMA guidelines was performed of articles published prior to March 2021. Articles were included in the review if a full‐text English version was available. Of the surveyed literature, 27 full‐text case reports were included in the final analysis. Benign eccrine poroma and porocarcinoma were the most common tumor subtypes (nine and eight cases, respectively). Males were only affected by poroma and porocarcinoma, while females were affected by all tumor subtypes. The first toe was the most common lower extremity affected. Misdiagnosis led to delayed treatment in 25% of cases. As such, while periungual eccrine neoplasms are rare diagnoses, the nonspecific presentations of these growths raise concerns about misdiagnosis and delayed treatment. Further research is needed related to sex‐differences in the epidemiology of these growths and into the prevalence of the first toe as a location. These tumors should be considered in the differential diagnosis for nail unit afflictions.

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Section: Hidradenocarcinomamentioning

confidence: 99%

A systematic review of periungual eccrine neoplasms

Rao

Knackstedt

2021

Int J Dermatology

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“…SEC most often present in the fourth to seventh decade of life and present as a solitary, firm nodule or plaque on the head, neck and less commonly trunk 4 . To the best of our knowledge, while only 9 cases of SEC were located on the extremities 5 6 7 8 9 10 .…”

Section: Introductionmentioning

confidence: 77%

“…The current case also exhibited a coin sized solitary pinkish nodule with fine telangiectasis. To the best of our knowledge, only 10 cases of SEC presented on the extremities, including our case, have been reported ( Table 1 ) 5 6 7 8 9 10 . In this series of 10 cases, there were 7 women and 3 men, ranging age at diagnosis of SEC from 42 to 94 years with an average age of 56 years.…”

Section: Discussionmentioning

confidence: 94%

Syringoid Eccrine Carcinoma of the Thigh

et al. 2017

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Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. It is usually present in the head, neck and trunk region, and often occurs in the fourth to seventh decades of life. A 94-year-old male patient visited our department with an 80-year history of a lesion showing a 2×2 cm sized well-demarcated round shaped erythematous to pinkish colored nodule with ulcer on his left thigh. Histological findings revealed a tumor consisted mainly of numerous small cords and nests forming luminal or tubular structures and tumor cells showing variable atypia. Some ductal structures showed tadpole appearance. On immunohistochemical staining, epithelial membrane antigen, S-100, cytokeratin 7 and carcinoembryonic antigen were reactive and Ki-67 showed less than 10% positivity. Based on these findings, the final diagnosis was made as SEC. The patient was treated with local wide excision and didn't show any recurrence during the follow-up period of 12 months. Herein, we report a very rare case of SEC which occurred on the left thigh and discuss 10 cases of SEC presented on the extremities, including our case.

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“…Less commonly, it may involve the trunk, as well as the upper and lower extremities. Reports of SEC involving other rare locations, including the nipple, 14 vulva, 15 and nail complex, 7 have also been documented. The tumor usually has an indolent course, often growing over years before the lesion becomes clinically apparent.…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the extremities, particularly the distal extremities, in SEC is uncommon. Rare cases of SEC presenting on the palm of the hand 6 and the great toe nail complex 7 have been previously reported. However, to the best of our knowledge, there have been no reported cases of SEC presenting on the sole of the foot.…”

Section: Introductionmentioning

confidence: 99%

Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm

Cho

Wagner²,

Gulosh

et al. 2017

Int J Surg Pathol

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Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Histologically, incisional biopsy revealed a tumor consisting of tubulocystic structures lined by basaloid cells with an infiltrative growth pattern, extending from the reticular dermis to the deep biopsy margin. Some of the nests and cords of basaloid cells displayed syringoma-like, tadpole morphology. Immunohistochemical analysis showed diffuse immunoreactivity with monoclonal carcinoembryonic antigen, epithelial membrane antigen, cytokeratin 7, S100 protein, and CD117. These morphologic and immunophenotypic features were most consistent with syringoid eccrine carcinoma. Syringoid eccrine carcinoma has a broad differential diagnosis which must be carefully ruled out by morphology, immunohistochemistry, and thorough metastatic survey with imaging studies. Our case highlights the importance of recognizing this rare entity, which is locally destructive and has a propensity for recurrence. To the best of our knowledge, this is the first reported case of syringoid eccrine carcinoma presenting on the sole of the foot.

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Subungual Syringoid Eccrine Carcinoma of the Great Toe Nail Complex

Cited by 7 publications

References 3 publications

A systematic review of periungual eccrine neoplasms

A systematic review of periungual eccrine neoplasms

Syringoid Eccrine Carcinoma of the Thigh

Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm

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