Subungual keratoacanthoma-a report of four cases and review of the literature

Oliwiecki, S.; Peachey, R. D. G.; Bradfield, J. W. B.; Ellis, J. P.; Lovell, C. R.

doi:10.1111/j.1365-2230.1994.tb01173.x

Cited by 37 publications

(27 citation statements)

References 16 publications

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“…These borderline tumors are histologically different from KA and SCC and show regression only in a few cases (Table ). Even if subungual KA show rather progressive growth than spontaneous involution, cellular atypia and the mitotic index are reduced compared to SCC and several authors consider it to be benign .…”

Section: Discrimination: Ka Versus Sccmentioning

confidence: 99%

Keratoacanthoma: a distinct entity?

Gleich

Chiticariu

Huber

et al. 2015

Experimental Dermatology

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Keratoacanthoma (KA) are common but exceptional benign tumors, often appearing on sun-exposed areas of light skinned people and showing spontaneous resolution. The goal of this study was to review existing literature, to point out the etiological complexity of KA biology and to answer the controversial debate if or not KA is a distinct entity or a variant of squamous cell carcinoma (SCC). Relying on recent results, we highlight that KA is an individual lesion with a unique molecular signature caused by alterations in the TGFb signalling pathway. These recent findings will help to understand the nature of KA and to develop new reliable diagnostic tools, simplifying the discrimination of the histologically similar KA and SCC.

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Section: Discrimination: Ka Versus Sccmentioning

confidence: 99%

Keratoacanthoma: a distinct entity?

Gleich

Chiticariu

Huber

et al. 2015

Experimental Dermatology

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“…DKA usually shows rapid growth, younger age of onset, and early bone destruction. [1][2][3][4][5] SCC occurs in elderly patients and discloses a slow growth, while bone changes are evident in a minority of cases. 5 However, in some cases differentiation is quite impossible.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] In contrast with KA elsewhere, spontaneous regression is uncommon, and the treatment is often problematic with frequent recurrences after local excision. [1][2][3][4][5] We report a patient with a recurrent DKA of the proximal nail fold of the left fifth finger, effectively treated with Mohs micrographic surgery (MMS).…”

Section: Introductionmentioning

confidence: 99%

Recurrent distal digital keratoacanthoma of the periungual region treated with Mohs micrographic surgery

Cecchi¹,

Troiano²,

Buralli³

et al. 2010

Aust J Dermatology

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We report a 42-year-old man who presented with a recurrent painful nodule on the proximal nail fold of the left fifth finger. The tumour had been surgically excised at another department a month earlier, and histological examination had shown a keratoacanthoma. The patient underwent Mohs micrographic surgery, and no recurrence was evident 16 months later. Mohs micrographic surgery appears to be an effective option in the management of this unusual variant of keratoacanthoma, which is often difficult to eradicate.

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“…Sun exposure, tar, mineral oil, steel wool, and human papilloma virus have been suggested as contributing factors to the formation of subungual keratoacanthoma [31].…”

Section: Subungual Keratoacanthomamentioning

confidence: 99%

Subungual tumors

Dooley

Kindt

Baratz

2012

HAND

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A 60-year-old man described a 15-year history of intermittent drainage from beneath the nail plate of his left long finger. The drainage began years after the subject sustained an injury in which a thorn became embedded beneath the nail. The patient had performed a number of self-debridements over the years. He had taken oral antibiotics on multiple occasions. In the 6 months prior to presentation, the drainage became more constant along with pain and erythema. On presentation, the nail plate had a central, 2-mm defect with granulomatous tissue underneath and longitudinal melanonychia. The nail plate was tender and minimal serosanginous drainage could be expressed. The remainder of the finger and nail complex appeared normal. Radiographs of the finger were normal.

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Subungual keratoacanthoma-a report of four cases and review of the literature

Cited by 37 publications

References 16 publications

Keratoacanthoma: a distinct entity?

Keratoacanthoma: a distinct entity?

Recurrent distal digital keratoacanthoma of the periungual region treated with Mohs micrographic surgery

Subungual tumors

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