Subungual Bowen's disease treated by topical aminolevulinic acid—photodynamic therapy

Usmani, N.; Stables, G.I.; Telfer, Nicholas R.; Stringer, Maurice

doi:10.1016/j.jaad.2005.03.056

Cited by 39 publications

(22 citation statements)

References 37 publications

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“…The safest treatment is micrographic surgery, but many less invasive and non-surgical treatments such as laser ablation, cryotherapy, photodynamic therapy, topical 5-fluorouracil and topical imiquimod have been used in selected cases [4,29,30,31]. However, given the risk of recurrence and in favour of our observation that koilocytes indicative of persistent HPV infection might remain at the margins in micrographic surgery (fig.…”

Section: Discussionmentioning

confidence: 92%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.

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Section: Discussionmentioning

confidence: 92%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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“…Topical PDT has been reported in case reports to clear BD in unusual sites (nipple and subungual) [70–72] and where it arises in a setting of poor healing (lower leg, epidermolysis bullosa and radiation dermatitis) [73–75]. In addition, topical ALA-PDT has been observed to offer therapeutic benefit in erythroplasia of Queyrat [76,77], a form of SCC in situ arising on the glans or prepuce, possibly induced by human papillomavirus [78].…”

Section: Clinical Applications Of Pdt For Cutaneous Neoplasiamentioning

confidence: 99%

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

Zhao¹,

He²

2010

Expert Review of Anticancer Therapy

137

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Photodynamic therapy (PDT) is a noninvasive procedure that involves a photosensitizing drug and its subsequent activation by light to produce reactive oxygen species that specifically destroy target cells. Recently, PDT has been widely used in treating non-melanoma skin malignancies, the most common cancer in the USA, with superior cosmetic outcomes compared with conventional therapies. The topical 'photosensitizers' commonly used are 5-aminolevulinic acid (ALA) and its esterified derivative methyl 5-aminolevulinate, which are precursors of the endogenous photosensitizer protoporphyrin IX. After treatment with ALA or methyl 5-aminolevulinate, protoporphyrin IX preferentially accumulates in the lesion area of various skin diseases, which allows not only PDT treatment but also fluorescence diagnosis with ALA-induced porphyrins. Susceptible lesions include various forms of non-melanoma skin cancer such as actinic keratosis, basal cell carcinoma and squamous cell carcinoma. The most recent and promising developments in PDT include the discovery of new photosensitizers, the exploitation of new drug delivery systems and the combination of other modalities, which will all contribute to increasing PDT therapeutic efficacy and improving outcome. This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions.Keywords 5-aminolevulinic acid; ALA; MAL; methyl 5-aminolevulinate; PDT; photodynamic therapy; photosensitizers; skin cancer; topical PDT Skin cancer is the most common form of cancer, accounting for nearly half of all cancers in the USA [1]. The most common types of skin cancer are non-melanoma skin cancers (NMSCs): basal cell carcinoma (BCC), which forms in the basal cells, and squamous cell carcinoma (SCC), which forms in the squamous cells. BCCs are rarely fatal, but can be † Author for correspondence: Tel.: +1 773 795 4696, Fax: +1 773 702 8398, yyhe@medicine.bsd.uchicago.edu. Financial & competing interests disclosureWork in the authors' laboratories was supported by the American Skin Association, the University of Chicago Cancer Research Center (P30 CA014599), and the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript. NIH Public Access Author ManuscriptExpert Rev Anticancer Ther. Author manuscript; available in PMC 2011 September 1. Genetic factors and environmental exposure to UV radiation in sunlight or tanning beds are strong risk factors for the genesis of skin cancer. Traditional skin c...

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“…Radiotherapy has been employed with good functional and cosmetic benefit for isolated or multiple lesions where progression to SCC has occurred. 143,144 Other recently described treatments are represented in case reports of the use of imiquimod, 145 PDT 79,80 and CO 2 laser ablation. 146 …”

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confidence: 99%

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

et al. 2014

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Subungual Bowen's disease treated by topical aminolevulinic acid—photodynamic therapy

Cited by 39 publications

References 37 publications

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

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