Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III

Ersryd, Amanda; Posserud, Iris; Abrahamsson, Hasse; Simrén, Magnus

doi:10.1111/j.1365-2036.2007.03422.x

Cited by 65 publications

(77 citation statements)

References 37 publications

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“…Sue et al encontraron el 46,7% con predominio mixto, el 25,4% con predominio de diarrea y el 24,1% con predominio de estreñimiento 29 . En contraste, Ersryd et al encontraron un perfil sintomático: SII con predominio de diarrea del 51,3%, SII indiferenciado del 31,2%, SII con predominio de estreñimiento del 8,9% y SII con predominio mixto del 8,46% 30 .…”

Section: Discussionunclassified

Factores sociosanitarios y prevalencia del síndrome del intestino irritable según los criterios diagnósticos de Roma III en una población general de Colombia

Álvarez

Vargas

Medina

et al. 2009

Gastroenterología y Hepatología

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Section: Discussionunclassified

Factores sociosanitarios y prevalencia del síndrome del intestino irritable según los criterios diagnósticos de Roma III en una población general de Colombia

Álvarez

Vargas

Medina

et al. 2009

Gastroenterología y Hepatología

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“…Therefore, symptoms of constipation, in conjunction with pain, lead to the diagnosis of IBS-C, which accounts for about 30% of IBS patients [16]. In the absence of abdominal pain, functional constipation has to be diagnosed.…”

Section: Functional Constipationmentioning

confidence: 99%

Somatic comorbidities of irritable bowel syndrome: A systematic analysis

Riedl

Schmidtmann

Stengel

et al. 2008

Journal of Psychosomatic Research

238

193

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“…1B ). An ANCOVA analysis revealed no infl uence of smoking habits on these results (F = 1.60, df = [1,63], P = 0.21).…”

Section: Arachidonic Acid Levelsmentioning

confidence: 99%

“…An ANOVA analysis did not reveal any differences between IBS subtypes or status ( Table 1 ). An ANCOVA analysis revealed no infl uence of smoking habits (PGE 2 : F = 0.85, df = [1,40], P = 0.36; LTB 4 : F = 0.66, df = [1,33], P = 0.42) or age (PGE 2 : F = 0.01, df = [1,40], P = 0.9; LTB 4 : F = 0.66, df = [1,33], P = 0.42) on these results.…”

Section: Eicosanoid Analysismentioning

confidence: 99%

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

Clarke

Fitzgerald

Hennessy

et al. 2010

Journal of Lipid Research

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Irritable bowel syndrome (IBS) is a common and potentially disabling, though nonfatal, medical disorder that can affect up to 20% of the population. It is the most common functional gastrointestinal disorder referred to gastroenterologists ( 1 ). Although it has evolved over the years in terms of nomenclature ( 2, 3 ), classifi cation ( 4-6 ), and appreciation of its frequency ( 7 ), a poor understanding of disease pathophysiology has remained a constant. According to the Rome III criteria, a symptom-based classifi cation system, the disease-defi ning symptom profi le encompasses abdominal pain and an altered bowel habit, with distension, bloating, and a variety of disturbances in defecatory function being additional features ( 8 ).The disorder is increasingly viewed as a disorder of the brain-gut axis, a construct describing a bidirectional interaction between the gastrointestinal tract (GIT), incorporating the intestinal epithelial barrier, the mucosa-associated lymphoid tissue (MALT), gut muscle and the enteric nervous system (ENS), and the central nervous system (CNS) ( 9, 10 ). Most recently, the proposal that low-grade infl ammation, as evidenced by the release of mast cell mediators and activation of lymphocytes in the colo-rectal mucosa and by the detection of elevated levels of pro-infl ammatory cytokines in serum ( 8,(11)(12)(13), has provided a new dimension to this paradigm. The source of this low-grade infl ammation, or immune activation, whether luminal or central, has remained elusive. Polyunsaturated fatty acids (PUFA) and their metabolites have been shown to infl uence infl ammatory processes ( 14 ). Moreover, a pro-infl ammatory PUFA profi le has recently been reported in the maternal separation rodent model, an animal model of IBS ( 15 ).Abstract Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder referred to gastroenterologists. Although the pathophysiology remains unclear, accumulating evidence points to the presence of low-level immune activation both in the gut and systemically. Circulating polyunsaturated fatty acids (PUFA) have recently attracted attention as being altered in a variety of disease states. Arachidonic acid (AA), in particular, has been implicated in the development of a pro-infl ammatory profi le in a number of immune-related disorders. AA is the precursor of a number of important immunomodulatory eicosanoids, including prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ). We investigated the hypothesis that elevated plasma AA concentrations in plasma contribute to the proposed pro-infl ammatory profi le in IBS. Plasma AA and related PUFA were quantifi ed by gas chromatography analysis in IBS patients and controls. Both PGE 2 and LTB 4 were measured in serum using commercially available ELISA assays. AA concentrations were elevated in our patient cohort compared with healthy controls. Moreover, we demonstrated that this disturbance in plasma AA concentrations leads to downstream elevations in eicosanoids. Together, our data identifi es...

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Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III

Abstract: SUMMARY BackgroundThe agreement between subtyping irritable bowel syndrome (IBS) patients based on Rome II criteria versus Rome III criteria is unknown.

Cited by 65 publications

References 37 publications

Factores sociosanitarios y prevalencia del síndrome del intestino irritable según los criterios diagnósticos de Roma III en una población general de Colombia

Factores sociosanitarios y prevalencia del síndrome del intestino irritable según los criterios diagnósticos de Roma III en una población general de Colombia

Somatic comorbidities of irritable bowel syndrome: A systematic analysis

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

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