Subtyping, phenotyping or endotyping rosacea: how can we improve disease understanding and patient care?

Thyssen, Jacob P.

doi:10.1111/bjd.16942

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Rosacea has been associated with a series of cardiovascular diseases, gastrointestinal disorders, neurologic disorders, and psychiatric disorders [12,76,77]. Wollina noted that rosacea was associated with metabolic, psychiatric, and neurologic disorders and specific types of cancer, and Wollina suggested that rosacea should be considered a systemic disease [78].…”

Section: Systemic Comorbiditiesmentioning

confidence: 99%

“…In 2002, rosacea was classified into the following four subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular [9]. In 2017, a phenotype-based approach for diagnosis and classification was recommended [2,[10][11][12]. Fixed centrofacial erythema and phymatous changes are independently considered as diagnostic criteria for rosacea [10].…”

Section: Introductionmentioning

confidence: 99%

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Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

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Section: Systemic Comorbiditiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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“…Fixed centrofacial erythema and phymatous changes are particularly considered as diagnostic criteria for rosacea. Rosacea in most cases is not a life-threatening disease, with a very good overall prognosis (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Chronic Inflammatory Dermatosis: Rosacea, Overview, Description, Presentation, Epidemiology, Pathophysiology, Types, Differential Diagnosis, Treatment of the Disease and Its Role in Pregnancy

Bryam Esteban Coello García,

María Belén Gutama Baculima,

Barbara Tatiana Reyes Moscoso

et al. 2023

EPRA

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Introduction: Rosacea is a chronic inflammatory dermatosis involving especially the cheeks, nose, chin and forehead, characterized by repetitive episodes of transient flushing or erythema, persistent erythema, in addition to phymatous changes, papules, pustules and telangiectasias. Objective: to detail the current information related to rosacea, description, presentation, epidemiology, pathophysiology, types, differential diagnosis, treatment of the disease and its role in pregnancy. Methodology: a total of 50 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 39 bibliographies were used because the other articles were not relevant to this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: rosacea, treatment, chronic inflammatory dermatosis. Results: Phymatous changes are not frequent, however they occur primarily in the nose (rhinophyma) and more commonly in men. Rosacea usually begins between 30 and 50 years of age, however it can occur at any age. The approximate population prevalence is between less than 1 to 22%. The neurocutaneous mechanisms in rosacea, reflecting reactivity to temperature change, alcohol, sports, UV rays and spicy foods, may be mediated by the ankyrin and vanilloid subfamilies of the transient receptor potential (TRP). Increased rosacea can occur in pregnancy and multiple cases linked to rosacea fulminans (RF) are reported in the literature. Conclusions: Rosacea is characterized by repetitive episodes of redness, persistent erythema, inflammatory papules-pustules and telangiectasias. Previously rosacea was divided into ocular, phymatous, fulminant and granulomatous types, however there is now a new classification of rosacea. In the treatment the first thing is to identify the trigger, then make some general recommendations on the skin such as the use of sunscreen and finally give treatment that can be both topical and systemic or even to use laser or other procedures. The differential diagnosis of rosacea is broad and should be carefully analyzed. Treatment in pregnant women is a huge challenge, because several of the treatments for rosacea are contraindicated or have limited evidence of probable side effects to the fetus. KEYWORDS: rosacea,treatment,dermatosis,inflammatory.

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“…В 2002 г. розацеа была классифицирована на следующие четыре подтипа: эритематозно-телеангиэктатическая, папуло-пустулезная, фиматозная и офтальмологическая [9]. В 2017 г. был рекомендован фенотипический подход для диагностики и классификации [2,[10][11][12]. Фиксированная центрально-лицевая эритема и фиматозные изменения независимо друг от друга рассматриваются как диагностические критерии розацеа [10].…”

Section: Introductionunclassified

The role of dermatocosmetics in the management of rosacea

Tserikidze,

Sakaniya,

Olenich

et al. 2023

Medicinskij sovet

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Rosacea is a chronic inflammatory disease that affects the facial skin. This pathology is characterized by hyperaemia, erythema, telangiectasia and other manifestations. It is also accompanied by a group of unpleasant symptoms, such as burning sensations, itching, and skin tightness. The pathogenesis of the disease has not been sufficiently studied. But it is generally accepted that it is based on abnormalities in the immune system. In addition, excessive Demodex colonization and exposure to ultraviolet radiation may play a role in the development of rosacea. The incidence rate of rosacea worldwide reaches 5%. It is emphasized that some ethnicities face a greater risk of this disease than others. It is a very difficult task to treat rosacea for a specialist. The therapeutic approach differs in different forms of the disease. There is a wide range of treatments available for papulopustular rosacea, including systemic and topical medications and even physiotherapy. However, the therapy of erythematous rosacea mainly centres around the use of dermatocosmetic care. For patients with rosacea, it is important to choose products that, first of all, can effectively reduce skin redness and discomfort and will be well tolerated. A dermo-cosmetic composition has to have an anti-inflammatory effect and the ability to repair damaged skin. This article presents our own experience of using such drug in the monotherapy of erythematous rosacea and in the complex treatment of papulopustular disease. A significant effect had been achieved at 3–4 weeks of complex therapy in patients with papulopustular rosacea. We present a clinical case report of a 46-year-old patient N. as an example of the effectiveness of therapy.

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Subtyping, phenotyping or endotyping rosacea: how can we improve disease understanding and patient care?

Abstract: Linked Articles: Tan et al. Br J Dermatol 2018; 179:741–746. Gether et al. Br J Dermatol 2018; 179:282–289.

Cited by 4 publications

References 7 publications

Rosacea Treatment: Review and Update

Rosacea Treatment: Review and Update

Chronic Inflammatory Dermatosis: Rosacea, Overview, Description, Presentation, Epidemiology, Pathophysiology, Types, Differential Diagnosis, Treatment of the Disease and Its Role in Pregnancy

The role of dermatocosmetics in the management of rosacea

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