Subtyping of COVID-19 samples based on Cell-Cell interaction in single cell transcriptomes
Kyeonghun Jeong,
Yooeun Kim,
Jaemin Jeon
et al.
Abstract:In single-cell transcriptome analysis, numerous biomarkers related to COVID-19 severity, including cell subtypes, genes, and pathways, have been identified. Nevertheless, most studies have focused on severity groups based on clinical features, neglecting immunological heterogeneity within the same severity level. In this study, we employed sample-level clustering using cell-cell interaction scores to investigate patient heterogeneity and uncover novel subtypes. The clustering results were validated using exter… Show more
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