Subtypes of recurrent abdominal pain based on the Rome Criteria for functional gastrointestinal disorders

Walker, Lynn S.; Lipani, Tricia A.; Greene, John W.; Caines, Karen; Stutts, John T.; Polk, D. Brent; Caplan, Arlene; Rasquin-Weber, Andrée

doi:10.1016/s0016-5085(03)81965-0

Cited by 3 publications

(2 citation statements)

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“…The inclusion criteria included a previous diagnosis of ASD based on documented ADOS (Autism Diagnostic Observation Schedule [48]) scores as well as meeting criteria for functional constipation, functional diarrhea, and/or irritable bowel syndrome (IBS) based on the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-RIII) diagnostic criteria [49] as completed by the parent. All participants were screened via parental interview for current and past physical illnesses and medication use over the past 3 months.…”

Section: Methodsmentioning

confidence: 99%

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

et al. 2019

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Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium infantis) in combination with a bovine colostrum product (BCP) as a source of prebiotic oligosaccharides and to evaluate GI, microbiome and immune factors in children with ASD and GI co-morbidities. This pilot study is a randomized, double blind, controlled trial of combination treatment (BCP + B. infantis) vs. BCP alone in a cross-over study in children ages 2–11 with ASD and GI co-morbidities (n = 8). This 12-week study included 5 weeks of probiotic-prebiotic supplementation, followed by a two-week washout period, and 5 weeks of prebiotic only supplementation. The primary outcome of tolerability was assessed using validated questionnaires of GI function and atypical behaviors, along with side effects. Results suggest that the combination treatment is well-tolerated in this cohort. The most common side effect was mild gassiness. Some participants on both treatments saw a reduction in the frequency of certain GI symptoms, as well as reduced occurrence of particular aberrant behaviors. Improvement may be explained by a reduction in IL-13 and TNF-α production in some participants. Although limited conclusions can be drawn from this small pilot study, the results support the need for further research into the efficacy of these treatments.

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Section: Methodsmentioning

confidence: 99%

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

et al. 2019

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“…The Rome II criteria established by consensus of an expert group in 1999 defined a group of functional disor-ders specific to childhood (6). Attempts at validating these criteria in clinical practice have been limited (10).…”

Section: Validation Of the Rome II Diagnostic Criteria At General Pra...mentioning

confidence: 99%

Functional Gastrointestinal Disorders, Gastroesophageal Reflux and Neurogastroenterology: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition

Di Lorenzo,

Benninga,

Forbes

et al. 2004

J. pediatr. gastroenterol. nutr.

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Research Investigation of enteric neurobiology and development of the enteric nervous system. Neuro‐immunology and the gut: characterization of the interactions between the central nervous system, enteric nervous system and immune system. Evaluation of the role of early life events in the development of functional gastrointestinal disorders. Intervention evelopment of multicenter, controlled studies aimed at evaluating epidemiology, pathophysiology and treatment of functional bowel disorders. Creation of a tissue bank for children with enteric neuromuscular disorders. Validation of the Rome II diagnostic criteria at the general practitioner and specialty level. Education Train physicians and researchers in performing motility, sensory, and laboratory assessment in the field of enteric neuromuscular disorders. Educate primary care physicians in the evaluation and treatment of GER and other functional bowel disorders. Educate care providers on the high incidence of enteric neuromuscular disorders and the special needs of children with neurologic handicaps.

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Functional Gastrointestinal Disorders, Gastroesophageal Reflux and Neurogastroenterology: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition

Lorenzo

Benninga

Forbes

et al. 2004

Journal of Pediatric Gastroenterology and Nutrition

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Subtypes of recurrent abdominal pain based on the Rome Criteria for functional gastrointestinal disorders

Cited by 3 publications

References 0 publications

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Functional Gastrointestinal Disorders, Gastroesophageal Reflux and Neurogastroenterology: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition

Functional Gastrointestinal Disorders, Gastroesophageal Reflux and Neurogastroenterology: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition

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