Subtypes of Minimal Residual Disease and Outcome for Stage II Colon Cancer Treated by Surgery Alone

Murray, Nigel P; Aedo, Sócrates; Villalon, Ricardo; Albarran, Vidal; Orrego, Shenda; Guzman, Eghon

doi:10.2139/ssrn.3551408

Cited by 1 publication

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“…When this statement is in concern the main line of thought is the fact that identifying CTC or liquid biopsy before surgery is of little interest, while the negative result after surgery does not imply MRD. The presence of bone marrow micro metastasis (BMMM) (Viehl et al 2017 ) seems to be an indicator of poor survival prognosis at 3 (68.4%) and 5 years (62.7%) follow-up (Murray et al 2020 ). In this manner CTC, liquid biopsy cannot be used in the stratification of patients for treatment but rather for follow-up.…”

Section: Discussionmentioning

confidence: 99%

Interactions of occult tumor spread and surgical technique on overall and disease-free survival in patients operated for stage I and II right-sided colon cancer

Banipal

Štimec

Andersen

et al. 2021

J Cancer Res Clin Oncol

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Purpose To determine if “medial to lateral” (ML) dissection with devascularization first is superior to “lateral to medial” (LM) dissection regarding numbers of lymph node micro metastases (MM) and isolated tumor cells (ITC) as well as 5-year disease-free (5YDFS) and 5-year overall survival (5YOS) in stage I/II right-sided colon cancer. Methods Two datasets are used. ML group consists of consecutive stage I/II patients from a prospective trial. LM group is the original dataset from a previous publication. All harvested lymph nodes are examined with monoclonal antibody CAM 5.2 (immunohistochemically). Lymph node harvest and 5YOS/5YDFS were compared between ML/LM groups, stage I/II tumors and MM/ITC presence/absence. Results 117 patients included ML:51, LM:66. MM/ITC positive in ML 37.3% (19/51), LM 31.8% (21/66) p = 0.54. The 5YDFS for patients in ML 70.6% and LM 69.7%, p = 0.99, 5YOS: 74.5% ML and 71.2% LM (p = 0.73). No difference in 5YDFS/5YOS between groups for Stage I/II tumors; however, LM group had an excess of early tumors (16) when compared to ML group, while lymph node harvest was significantly higher in ML group (p < 0.01) 15.1 vs 26.7. 5YDFS and 5YOS stratified by MM/ITC presence/absence was 67.5%/71.4%, p = 0.63, and 75.0%/71.4%, p = 0.72, respectively. Death due to recurrence in MM/ITC positive was significantly higher than MM/ITC negative (p = 0.012). Conclusion Surgical technique does not influence numbers of MM/ITC or 5YDFS/5YOS. Presence of MM/ITC does not affect 5YOS/5YDFS but can be a potential prognostic factor for death due to recurrence. Clinical trial Safe Radical D3 Right Hemicolectomy for Cancer through Preoperative Biphasic Multi-Detector Computed Tomography (MDCT) Angiography” registered at http://clinicaltrials.gov/ct2/show/NCT01351714 .

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Section: Discussionmentioning

confidence: 99%