Subtypes of Family History and Conduct Disorder Effects on P300 During the Stroop Test

Bauer, Lance O.; Hesselbrock, Victor

doi:10.1016/s0893-133x(98)00139-0

Cited by 76 publications

(53 citation statements)

References 53 publications

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“…Twin research studies have yielded evidence of common genetic factors underlying pairs of disorders within this spectrum (Grove et al, 1990;Pickens, Svikis, McGue, & LaBuda, 1995;Slutske et al, 1998). Moreover, recent large-scale epidemiological studies with twins have shown that the broad externalizing factor, reflecting the shared variance among disorders of this type, is substantially (>80%) heritable (Kendler, Prescott, Myers, & Neale, 2003;Krueger et al, 2002;Young, Stallings, Corley, Krauter, & Hewitt, 2000).Of particular relevance to the current study is growing evidence that reduced P300 response is associated with other disorders in the externalizing spectrum besides alcohol dependence, including drug dependence (Attou, Figiel, & Timsit-Berthier, 2001;Biggins, MacKay, Clark, & Fein, 1997;Branchey, Buydens-Branchey, & Horvath, 1993), nicotine dependence (Anokhin et al, 2000;Iacono et al, 2002), child conduct disorder (Bauer & Hesselbrock, 1999a, 1999bKim, Kim, & Kwon, 2001), and adult antisocial personality Costa et al, 2000). Furthermore, reduced P300 is associated with risk for these other disorders as well as with active symptoms.…”

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confidence: 70%

P300 amplitude as an indicator of externalizing in adolescent males

et al. 2006

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Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism is part of a broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized that reduced P300 is an indicator of the common factor that underlies disorders within this spectrum. Community males (N=969) were assessed at age 17 in a visual oddball task. Externalizing was defined as the common factor underlying symptoms of alcohol dependence, drug dependence, nicotine dependence, conduct disorder, and adult antisocial behavior. A robust association was found between reduced P300 amplitude and the externalizing factor, and this relation accounted for links between specific externalizing disorders and P300. Our findings indicate that reduced P300 amplitude is an indicator of the broad neurobiological vulnerability that underlies disorders within the externalizing spectrum. Descriptors P300; externalizing; psychopathologyDiagnostic comorbidity studies and behavioral genetic investigations over the past decade have converged on the idea that alcoholism, drug dependence, and antisocial deviance in childhood and later life comprise a spectrum of related disorders. Coincident with these developments, evidence has accumulated that reduced amplitude of the P300 brain potential response, long known to be an indicator of risk for alcohol problems, is associated with other disorders in this spectrum. The current study addressed the following basic question, arising from these existing lines of evidence: Is reduced P300 amplitude an indicator of the general factor that these disorders have in common, rather than of specific disorders within this spectrum?It is well established that reduced amplitude of the P300 component of the event-related potential, a positive brainwave deflection evoked by infrequent, task-relevant events in a stimulus sequence, is associated with alcohol problems and alcoholism risk. 1 This link was first noted in work comparing abstinent alcoholics with controls (Porjesz, Begleiter, & Garozzo, 1980). Subsequent studies revealed that reduced P300 amplitude was associated not just with active symptoms, but also with risk for the development of alcohol problems. For example, children and adolescents with a paternal history of alcoholism show reliably reduced P300 compared with family-negative controls (Begleiter, Porjesz, Bihari, & Kissin, 1984;Elmasian, Neville, Woods, Schuckit, & Bloom, 1982;Hill & Shen, 2002; for review, see Address reprint requests to: Christopher J. Patrick, Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Road, Minneapolis, MN 55455, USA; E-mail: cpatrick@tc.umn.edu. 1 The term P3b is sometimes used for this frequency-sensitive component, to distinguish it from the "P3a" or "novelty P3," maximal at fronto-central sites, which follows the occurrence of an unexpected rare nontarget stimulus (Coles & Rugg, 1995). Unless otherwise specified, "P300" here refers to the P3b compo...

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confidence: 70%

P300 amplitude as an indicator of externalizing in adolescent males

et al. 2006

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“…Furthermore, P300 amplitude correlates negatively with APD symptom counts and retrospectively assessed CD symptoms (Costa et al, 2000). Reductions in P300 amplitude have also been reported among adolescents with CD in both auditory (Bauer & Hesselbrock, 2003) and visual oddball tasks (Bauer & Hesselbrock, 1999a;Iacono, Carlson, Malone, & McGue, 2002;Iacono, Malone, & McGue, 2003) as well as the Stroop task (Bauer & Hesselbrock, 1999b). Recent work has demonstrated that the latent externalizing factor representing the covariance (shared or overlapping variance) among APD, CD, and substance use disorders is also related to reduced P300 amplitude (Patrick, Bernat, Malone, Iacono, Krueger, & McGue, 2006).…”

Section: Aggression and P300mentioning

confidence: 92%

Violent offending predicts P300 amplitude

Bernat

Hall

Steffen

et al. 2007

International Journal of Psychophysiology

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Prior work has consistently revealed a relationship between antisocial behavior and reduced P300 amplitude. Fewer studies have directly evaluated behavioral indices of aggression and P300, and those that have generally do not account for potential mediating variables such as age, intelligence, and behavioral task performance. The current study assessed the relationship between the total number of convicted violent and non-violent offenses and P300 in a sample of inmates from a medium security state prison. Violent offenses evidenced a robust negative relationship with P300 amplitude, whereas non-violent offenses did not. Additional analyses evaluated age, intelligence, and behavioral task performance as potential mediating variables. Only reaction time significantly predicted P300 amplitude, and mediational analyses showed that this relationship did not account for the violentoffense/P300 relationship. Findings are discussed in terms of personality correlates and neurobiological process related to aggression.There is long-standing interest in the notion that antisocial behavior, and aggression in particular, involves neurobiologically-based deficits in information processing. Neuropsychological research has revealed that antisocial behavior is associated with impaired executive function (c.f. Morgan & Lilienfeld, 2000), and neuroimaging studies have consistently identified frontal lobe abnormalities among violent offenders (Goyer, Andreason, Semple, & Clayton, 1994;Raine, Buchsbaum, & LaCasse, 1997;Raine, Lencz, Bihrle, LaCasse, Colletti, 2000; Volkow, Tancredi, Lawrence, Grant, Gillespie, & Hampton, 1995). Furthermore, research using event-related brain potentials has indicated that antisocial behavior is associated with reduced P300 responses to task-relevant stimuli in target detection tasks (e.g., Iacono, Malone, & McGue, 2003). These deficits may reflect inefficient neural processing of salient environmental stimuli (Donchin & Coles, 1988), which could potentially contribute to risk for antisocial deviance.Notably, antisocial behavior encompasses both violent and nonviolent transgressions. One unresolved issue is whether P300 amplitude is associated with both violent and non-violent forms of antisocial behavior, or more predominantly with aggressive forms of acting out. Some research has examined P300 response in aggressive individuals specifically (e.g., Barratt, Stanford, Kent, & Felthous, 1997); this work has revealed that reduced P300 amplitude is selectively related to impulsive, but not instrumental, aggression. However, this work has not compared associations for aggressive versus non-aggressive offending behavior. Thus, the aim of the present study was to replicate and extend prior research on antisocial behavior and brain response by examining relations between violent and non-violent offenses and P300 amplitude in a sample of adult male inmates. Our prediction was that reduced P300 response would be Correspondence may be addressed either to Edward M. Bernat (email: ebernat@umn.edu) or Chri...

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“…In fact, the association is of such a magnitude that statistically controlling for the effects of conduct problems will typically eliminate the effects of FH on P300 (e.g., Bauer and Hesselbrock, 1999;Viana-Wackerman et al, 2007). …”

Section: Discussionmentioning

confidence: 99%

“…Participants performed a discreet trials version (Duncan-Johnson and Kopell, 1981;Bauer and Hesselbrock, 1999) of the Stroop Test (MacLeod, 1991;Stroop, 1935, van Venn andCarter, 2005) in which the stimuli, i.e., the words RED, BLUE, or TOWN, were presented in a red or blue font on the computer monitor. The 6 combinations of words and font colors could later be reduced to three types of trials.…”

Section: Data Collectionmentioning

confidence: 99%

The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve

Bauer

2008

Drug and Alcohol Dependence

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Background-The goal of the study was to test the validity of additive versus synergistic versus underadditive versions of brain reserve theory within the context of HIV/AIDS. In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence.Methods-Seventy HIV-1 seronegative and 115 HIV-1 seropositive male and female volunteers were assigned to 4 subgroups defined by the crossing of a VIQ score < versus ≥ 90 with the presence versus absence of a paternal history of alcohol, cocaine, or opiate abuse or dependence. The principal dependent measure was the P300 event related brain potential elicited during the Stroop color-word interference task.

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Subtypes of Family History and Conduct Disorder Effects on P300 During the Stroop Test

Cited by 76 publications

References 53 publications

P300 amplitude as an indicator of externalizing in adolescent males

P300 amplitude as an indicator of externalizing in adolescent males

Violent offending predicts P300 amplitude

The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve

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