Subtype distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype

Stensvold, Christen Rune; Alfellani, Mohammed A.; Nørskov-Lauritsen, Sara; Prip, Katrine; Victory, Emma L.; Maddox, Charlotte; Nielsen, Henrik Vedel; Clark, C. Graham

doi:10.1016/j.ijpara.2008.07.006

Cited by 254 publications

(303 citation statements)

References 32 publications

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“…Of the STs that are rare in humans, only ST9 is yet to be reported from non-human sources. Although ST5 is rare in humans, it is found commonly in captive apes, although not in other NHPs (Stensvold et al, 2009a). Its highest frequency seems to be in livestock, particularly cattle, pigs, sheep and camels (Stensvold et al, 2009a).…”

Section: Blastocystismentioning

confidence: 99%

“…ST4 is common in Europe, but is rarely reported from Asian, Middle Eastern and South American populations; however, in many regions comparatively little sampling has been undertaken. ST3 is the most common subtype in humans worldwide, and its occurrence is a frequent finding in analyses of subtype distribution, irrespective of the geographic origin of the population (Forsell et al, 2012;Malheiros et al, 2011;Meloni et al, 2011;Nagel et al, 2011;Souppart et al, 2010;Souppart et al, 2009;Stensvold et al, 2009a;Stensvold et al, 2009b;Stensvold et al, 2011b). The high discriminatory index of the ST3 MLST system makes it useful for surveillance of ST3 strains (re-infection or recrudescence; longevity of colonisation; patterns of transmission), whereas that of ST4 would not be suitable for these purposes.…”

Section: Intra-subtype Diversitymentioning

confidence: 99%

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Recent Developments in Blastocystis Research

Clark

Giezen

Alfellani

et al. 2013

Advances in Parasitology

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216

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Abstract:Blastocystis is a common parasite of the human large intestine but has an uncertain role in disease. In this review, we appraise the published evidence addressing this and its weaknesses. Genetic diversity studies have led to the identification of numerous subtypes within the genus Blastocystis and, recently, methods for studying variation within subtypes have been developed, with implications for our understanding of host specificity. The geographic distribution of subtypes is summarised and the impact this may have on investigations into the role of the organism in disease is discussed. Finally, we describe the organelle and nuclear genome characteristics and look to future developments in the field.

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Section: Blastocystismentioning

confidence: 99%

Section: Intra-subtype Diversitymentioning

confidence: 99%

Recent Developments in Blastocystis Research

Clark

Giezen

Alfellani

et al. 2013

Advances in Parasitology

Self Cite

251

216

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show abstract

“…[5][6][7] Blastocystis organisms found in different hosts are morphologically indistinguishable. However, this genus exhibits an extensive genetic diversity and at least 13 subtypes (STs) have been described on the basis of molecular data, [8][9][10] which showed sufficient genetic divergence to be classified as separate species. 11 Moreover, nine of these STs (ST1-ST9) have been isolated from human fecal samples highlighting both the low host specificity of the parasite and its zoonotic potential.…”

mentioning

confidence: 99%

“…11 Moreover, nine of these STs (ST1-ST9) have been isolated from human fecal samples highlighting both the low host specificity of the parasite and its zoonotic potential. [9][10][11] In the recent literature, it is still in debate whether distinct Blastocystis STs correlate with the development of gastrointestinal symptoms caused by the parasite. 1,4,5,12,13 Moreover, information on the distribution of STs in some geographic locations including Middle Eastern countries is only starting to emerge.…”

mentioning

confidence: 99%

Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms

Safadi¹,

Meloni²,

Poirier³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Blastocystis is the most common eukaryotic parasite in the intestinal tract of humans. Because of its potential impact in public health, we acquired the first data concerning the prevalence of this parasite and the frequency of the Blastocystis subtypes (STs) in the Lebanese population. In this study, fecal samples from 220 Lebanese symptomatic and asymptomatic patients were collected and a total of 42 patients (19%) were identified as positive for this parasite by directlight microscopy of smears. Among these, 36 Blastocystis isolates were genotyped using partial small subunit ribosomal RNA gene sequencing. The ST distribution in the present Lebanese population was as follows:

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“…This paper proposed that all isolates fall within nine subtypes and concluded that a standardisation within the nomenclature would make future epidemiological and clinical studies much easier. Since this paper was published, a further eight subtypes have been identified from animals [7][8][9]. Recently the whole genome sequence for subtype (ST) 7 was completed.…”

Section: Introductionmentioning

confidence: 99%

Update on the Molecular Epidemiology and Diagnostic Tools for Blastocystis sp

Roberts¹,

Stark²,

Harkness³

et al. 2014

J Med Microb Diagn

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Blastocystis is the most common enteric protist found in humans. Due to the recent advancements in molecular technologies, up to 17 subtypes have been identified from humans and animals. Molecular epidemiological studies have shown the large range of subtype (ST) distribution within geographical locations with ST1-9 being identified in humans. ST3 has been identified as the predominant subtype in most epidemiological studies with a considerable absence of ST4 noted in Africa and the Middle East compared to Europe and Australia where this subtype is fairly common. This review summarises the molecular tools used for diagnosis and speciation of Blastocystis and comments on advancements in the area over the last 15 years and what future trends may be. This review also describes the geographical distribution of Blastocystis and comments on possible intra-subtype evolutionary relationships.

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Subtype distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype

Cited by 254 publications

References 32 publications

Recent Developments in Blastocystis Research

Recent Developments in Blastocystis Research

Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms

Update on the Molecular Epidemiology and Diagnostic Tools for Blastocystis sp

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