2020
DOI: 10.1039/d0en00844c
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Subtoxic dose of lithium cobalt oxide nanosheets impacts critical molecular pathways in trout gill epithelial cells

Abstract: Global transcriptomics uncovered key molecular processes impacted by subtoxic dose of lithium cobalt oxide nanoparticles, indicating cellular attempts to restore energy and oxygen balance.

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Cited by 5 publications
(22 citation statements)
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References 65 publications
(84 reference statements)
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“…These functions are likely activated as part of the cellular response to the NP insult, which has been reported to include strong ROS generation and oxidative stress, DNA and heme protein damage, and energy and oxygen related imbalance. 10 , 12 , 16 , 17 This interpretation is also supported by the observation that the averaged expression level of GAPDH significantly increased in response to all exposure conditions except the nontoxic dose at 24 h ( Figure 5 ).…”
Section: Resultssupporting
confidence: 67%
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“…These functions are likely activated as part of the cellular response to the NP insult, which has been reported to include strong ROS generation and oxidative stress, DNA and heme protein damage, and energy and oxygen related imbalance. 10 , 12 , 16 , 17 This interpretation is also supported by the observation that the averaged expression level of GAPDH significantly increased in response to all exposure conditions except the nontoxic dose at 24 h ( Figure 5 ).…”
Section: Resultssupporting
confidence: 67%
“…It has been also shown that under certain conditions, GLUT1 and GLUT4 expression is regulated in opposite directions. 51 Prior observations suggesting that LCO NPs induce hypoxia and other stress responses in these cells 17 might explain the more consistent increase in the expression of GLUT1 ( Figure 5 ) while decreasing the priority of GLUT4 relative to other more critical genes for cell survival under the NP insult ( Figure 7 D).…”
Section: Resultsmentioning
confidence: 83%
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