Subtle structural variations in new mixed-ligand Cu(II) complexes with NN'O type unsymmetrical Schiff bases: Molecular docking against SARS-Cov-2 and its Omicron variant main proteases

Ghasemi, Liana; Abedi, Anita; Abbasi, Alireza; Kucerakova, Monika; Dusek, Michal; Behzad, Mahdi

doi:10.1016/j.inoche.2023.111795

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…Salicylaldehyde or 2-hydroxy-benzaldehyde (saloH) is an organic compound found in the defensive secretion of some leaf beetle species [3]. Salicylaldehyde-based compounds are derivatives of saloH formed either by reactions through the carbonyl group leading to novel classes of compounds bearing the salicylaldehyde scaffold, such as Schiff bases [4][5][6][7], hydrazides [8,9], hydrazones [10][11][12][13], or thiosemicarbazones [14][15][16], or by the insertion of diverse substituents on one or more positions of the aromatic leading to substituted salicylaldehydes.…”

Section: Introductionmentioning

confidence: 99%

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules

Psarras,

Zianna,

Hatzidimitriou

et al. 2024

Inorganics

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Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of [Ni(3,5–diBr–salo)2(neoc)] was determined by single-crystal X-ray crystallography. According to employed studying techniques, the complexes interact tightly with calf-thymus DNA by an intercalative fashion. Furthermore, compounds 1–3 bind tightly and reversibly to human and bovine serum albumin.

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Section: Introductionmentioning

confidence: 99%

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules

Psarras,

Zianna,

Hatzidimitriou

et al. 2024

Inorganics

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“…[14][15][16] This family of compounds is excellent for the development of novel medications due to their high efficacy across numerous therapeutic fields. 15,[17][18][19][20][21][22][23] Schiff bases may also be employed as chelators for metals such as copper, zinc, and cadmium by forging links between metals with an oxygen or nitrogen atoms present in Schiff bases, which act as donors for metals. 18 These complexes have a wellestablished reputation for being effective antibacterial and antiviral agents.…”

Section: Introductionmentioning

confidence: 99%

New Schiff bases and their vanadium complexes: Synthesis, characterization, and biological assessment for antibacterial and antiviral action

Khaldoune,

Hasnaoui,

Rafya

et al. 2024

Applied Organom Chemis

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From the perspective of possible antiviral and antibacterial activity of vanadium‐based complexes, we report the synthesis of new Schiff base ligand (L4) and a new Schiff‐base‐vanadium complex (C2). Both the ligand and the complex were characterized by Fourier transform infrared spectroscopy and Nuclear magnetic resonance techniques. Single‐crystal X‐ray Diffraction analysis has been used to confirm the structure of ligand L4 and complex C2. In addition, L1–4 and C1–3 were tested for their antibacterial effects against Escherichia coli and Staphylococcus aureus. Among the compounds, L2 demonstrated the most potent inhibition of both bacteria, exhibiting the lowest values for minimum inhibitory concentration (CMI) and minimum bactericidal concentration (CMB) (CMI = 0.16, CMB = 0.31 against E. coli, and CMI = CMB = 0.16 against S. aureus). Additionally, L2 produced the largest inhibition zones with diameters of 15.5 ± 0.15 against E. coli and 14.5 ± 0.04 against S. aureus. Furthermore, the antiviral efficacy of L1, L2, L4, C1, C2, and C3 against RNA viruses was assessed. C2 and C3 exhibited the most potent antiviral activity among the tested compounds.

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“…Among the support substrates, 2D nanosheets have been found to exhibit excellent cocatalytic properties as they provide a growth platform with large surface area for active sites. , Recently, Schiff base macrocycles have drawn much attention due to their ease of preparation, rich carbon and nitrogen double bonds, and good biocompatibility, which makes them popular in biomaterials, − catalysis , and other fields. , In our previous study, we reported a series of [2 + 2], [2 + 3], and [2 + 4] Schiff base double-layer macrocycles derived from 2,2′-ethylenedianiline, and the [2 + 3] macrocycle nanosheets were selected for the incorporation of Pd due to its high yield, facile synthesis, and good stability. Currently, nanozymes based antimicrobial films with unique properties such as biodegradability, biocompatibility and antimicrobial activity are being rapidly developed in the field of food packaging, medical consumables, public goods, etc.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

Wang,

Redshaw,

Zhao

et al. 2024

ACS Appl. Nano Mater.

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The development of nanozymes has emerged as a promising pathway for combating bacterial infections. In this work, Ag/Schiff base nanozymes are obtained through the in situ reduction method on [2 + 3] Schiff base macrocycles using ecofriendly reductant α-tocopherol. The silver prepared was found to be nanoscale by TEM, and Ag NPs grew and dispersed uniformly on the surface of the Schiff base macrocycle due to the abundance of the C�N double bonds. The peroxidase-like catalytic activity of the Ag/Schiff base was evaluated toward 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 , and the K m values of 0.350 and 0.090 mM confirm the strong affinity of Ag/Schiff base for H 2 O 2 and TMB. Moreover, the nanozyme exhibited good antibacterial properties against Streptococcus sanguinis, Pseudomonas aeruginosa, and Staphylococcus aureus, and in vivo tests confirmed that the Ag/Schiff base had negligible biotoxicity. Benefiting from the good antimicrobial and biosafety properties, the nanozymes were explored to prepare antibacterial films, and the bacterial inhibition zones demonstrated that the introduction of the Ag/Schiff base could prevent the growth of bacteria.

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Subtle structural variations in new mixed-ligand Cu(II) complexes with NN'O type unsymmetrical Schiff bases: Molecular docking against SARS-Cov-2 and its Omicron variant main proteases

Cited by 7 publications

References 41 publications

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules

New Schiff bases and their vanadium complexes: Synthesis, characterization, and biological assessment for antibacterial and antiviral action

Silver Nanoparticle-Immobilized Schiff-Base Macrocycles as Nanozymes with Peroxidase Mimic Activity for Antibacterial Films

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