Subtle Cognitive Effects of Moderate Hypoxia

Hewett, Kate J.; Curry, Ian P; Rath, Edna; Collins, Stéphanie

doi:10.21236/ada511511

Cited by 17 publications

(10 citation statements)

References 2 publications

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“…Previous investigators have reported that cognitive function was impaired after 60 min of hypoxia exposure and complex cognitive tasks were impaired before simple tasks (Cudaback 1984;Adam et al, 2008;Hewett et al, 2009;Kryskow et al, 2013). The data support these previous investigations in that some of our indices of cognitive function were impaired during at the B-Hypo compared to B-Norm.…”

Section: Cognitive and Physiological Measurements At Rest In Hypoxiasupporting

confidence: 85%

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

Seo

Burns

Fennell

et al. 2015

High Altitude Medicine & Biology

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Although previous reports indicate that exercise improves cognitive function in normoxia, the influence of exercise on cognitive function in hypoxia is unknown. The purpose of this study was to determine if the impaired cognitive function in hypoxia can be restored by low to moderate intensity exercise. Sixteen young healthy men completed the ANAM versions of the Go/No-Go task (GNT) and Running Memory Continuous Performance Task (RMCPT) in normoxia to serve as baseline (B-Norm) (21% O2). Following 60 minutes of exposure to normobaric hypoxia (B-Hypo) (12.5% O2), these tests were repeated at rest and during cycling exercise at 40% and 60% of adjusted Vo2max. At B-Hypo, the % correct (p≤0.001) and throughput score (p≤0.001) in RMCPT were significantly impaired compared to B-Norm. During exercise at 40% (p=0.023) and 60% (p=0.006) of adjusted Vo2max, the throughput score in RMCPT improved compared to B-Hypo, and there was no significant difference in throughput score between the two exercise intensities. Mean reaction time also improved at both exercise intensities compared to B-Hypo (p≤0.028). Both peripheral oxygen saturation (Spo2) and regional cerebral oxygen saturation (rSo2) significantly decreased during B-Hypo (p≤0.001) and further decreased at 40% (p≤0.05) and 60% (p≤0.039) exercise. There was no significant difference in Spo2 or rSo2 between two exercise intensities. These data indicate that low to moderate exercise (i.e., 40%-60% adjusted Vo2max) may attenuate the risk of impaired cognitive function that occurs in hypoxic conditions.

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Section: Cognitive and Physiological Measurements At Rest In Hypoxiasupporting

confidence: 85%

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

Seo

Burns

Fennell

et al. 2015

High Altitude Medicine & Biology

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show abstract

“…As already stated, the difference of findings in literature on the effect of hypoxia on high cognitive process has been mainly explained by divergences in the methods used (Davranche et al, 2016). In many situations, however, no significant effects on cognitive performance have, as in the present study, been detected (Hewett, Curry, Rath, & Collins, 2009;Komiyama et al, 2015;Latshang et al, 2013;Legg et al, 2014;Pavlicek et al, 2005;Tripathi, Apte, & Mukundan, 2005). It can, therefore, be safely concluded that people's information integration capacities are not affected by hypoxia, even if acclimatization to it has not taken place, and as far as it is not too severe; that is, corresponding to an altitude that is lower than 4500 m.…”

Section: Figure 2 Patterns Of Results Showing the Perceived Relationscontrasting

confidence: 43%

Effect of Hypoxia on Information Integration Capacities

2018

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The effect of hypoxia on cognitive processes is an undisputed finding but its extent remains difficult to predict in each particular circumstance. The present study examined the impact of hypoxia on information integration capacities in daily life settings. A sample of 14 students was presented with a series of cards depicting an object a) having a given volume and made of a given substance, and asked to infer its mass;or b) having a given mass and density, and asked to infer its volume; or c) having a given volume and mass, and asked to infer its density. There were three levels of hypoxia situations. In a baseline situation, participants were instructed to put a mask connected with an AltiTrainer (equipment that regulates the oxygen partial pressure provided through the mask) and to perform the three judgment tasks in close succession. The two other situations were similar to the baseline situation except that the AltiTrainer was configured to simulate altitude levels either 1100 m or 3100 m higher than the one in the baseline situation. Contrary to our expectations, no difference in performance was found between the three experimental situations. People’s information integration capacities are not affected by hypoxia, even if acclimatization to it has not taken place, and as far as it is not too severe.

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“…In acute hypoxia, especially when it is probed in laboratory settings devoid of other confounding factors as cold, fatigue and high level of physical exertion, the altitude of up to 3880 (+/− 500) m have not produced reliable cognitive deterioration in numerous studies (for no effect see Crow and Kelman, 1973 ; Paul and Fraser, 1994 ; Gustafsson et al, 1997 ; Takagi and Watanabe, 1999 ; Hewett et al, 2009 ). In longer sojourns, hypoxia attenuates with long-term acclimatization on various physiological levels, for example, red blood cell count increases in the first 5–6 weeks (Zubieta-Calleja et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Extreme Environment Effects on Cognitive Functions: A Longitudinal Study in High Altitude in Antarctica

Barkaszi¹,

Takács²,

Czigler³

et al. 2016

Front. Hum. Neurosci.

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This paper focuses on the impact of long-term Antarctic conditions on cognitive processes. Behavioral responses and event-related potentials were recorded during an auditory distraction task and an attention network paradigm. Participants were members of the over-wintering crew at Concordia Antarctic Research Station. Due to the reduced partial pressure of oxygen this environment caused moderate hypoxia. Beyond the hypoxia, the fluctuation of sunshine duration, isolation and confinement were the main stress factors of this environment. We compared 6 measurement periods completed during the campaign. Behavioral responses and N1/MMN (mismatch negativity), N1, N2, P3, RON (reorientation negativity) event-related potential components have been analyzed. Reaction time decreased in both tasks in response to repeated testing during the course of mission. The alerting effect increased, the inhibition effect decreased and the orienting effect did not change in the ANT task. Contrary to our expectations the N2, P3, RON components related to the attentional functions did not show any significant changes. Changes attributable to early stages of information processing were observed in the ANT task (N1 component) but not in the distraction task (N1/MMN). The reaction time decrements and the N1 amplitude reduction in ANT task could be attributed to sustained effect of practice. We conclude that the Antarctic conditions had no negative impacts on cognitive activity despite the presence of numerous stressors.

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Subtle Cognitive Effects of Moderate Hypoxia

Cited by 17 publications

References 2 publications

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

Effect of Hypoxia on Information Integration Capacities

Extreme Environment Effects on Cognitive Functions: A Longitudinal Study in High Altitude in Antarctica

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