Subthalamic nucleus mediates the modulation on cocaine self‐administration induced by ultrasonic vocalization playback in rats

Montanari, Christian; Giorla, Elodie; Pelloux, Yann; Baunez, Christelle

doi:10.1111/adb.12710

Cited by 17 publications

(49 citation statements)

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“…This mirror our previous study showing that presentation of an unfamiliar peer after acquiring selfadministration alone induce positive ultrasonic vocalization and reduce self-administration (Giorla et al, 2018). In contrast, play back of negative USV transiently increase self-administration (Montanari et al, 2018). These results highlight the critical role of vocal communication in the influence of proximal social factors on drug consumption.…”

Section: Ultrasonic Vocalization and Drug Addictionsupporting

confidence: 88%

“…In a recent study, we have shown that the playback of positive USV of a nonfamiliar rat can reduce cocaine intake (Montanari et al, 2018). This mirror our previous study showing that presentation of an unfamiliar peer after acquiring selfadministration alone induce positive ultrasonic vocalization and reduce self-administration (Giorla et al, 2018).…”

Section: Ultrasonic Vocalization and Drug Addictionsupporting

confidence: 82%

“…STN lesions reduced the drug intake, but abolished the difference between familiar and unfamiliar peer (Giorla et al, data unpublished). In the experiment testing the effects of USV playback on cocaine intake, STN lesions blocked the influence of USV and cocaine intake remained stable (Montanari et al, 2018).…”

Section: Proximal Social Factorsmentioning

confidence: 99%

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Social modulation of drug use and drug addiction

et al. 2019

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This review aims to demonstrate how social science and behavioral neurosciences have highlighted the influence of social interactions on drug use in animal models. In neurosciences, the effect of global social context that are distal from drug use has been widely studied. For human and other social animals such as monkeys and rodents, positive social interactions are rewarding, can overcome drug reward and, in all, protect from drug use. In contrast, as other types of stress, negative social experiences facilitate the development and maintenance of drug abuse. However, interest recently emerged in the effect of so-called "proximal" social factors, that is, social interactions during drug-taking. These recent studies have characterized the role of the drug considered, the sharing of drug experience and the familiarity of the peer which interaction are made with. We also examine the few studies regarding the sensorial mediator of social behaviors and critically review the neural mediation of social factors on drug use. However, despite considerable characterization of the factors modulating distal influences, the mechanisms for proximal influences on drug use remain largely unknown.

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Section: Ultrasonic Vocalization and Drug Addictionsupporting

confidence: 88%

Section: Ultrasonic Vocalization and Drug Addictionsupporting

confidence: 82%

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Social modulation of drug use and drug addiction

et al. 2019

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“…In impulsivity tasks, STN lesion consistently increased the rate of trial omissions and response latency Robbins, 1997, 1999a;Winstanley et al, 2005), which can be interpreted as decreased motivation (Robbins, 2002;Higgins and Silenieks, 2017) (Figures 3, 6). However, when assayed using classical FR or PR operant tasks, STN lesion either increased (Baunez et al, 2002(Baunez et al, , 2005Uslaner et al, 2008;Montanari et al, 2018) or did not change (Baunez et al, 2005;Bezzina et al, 2008;Winter et al, 2008) self-administration of food or sucrose. Decreased cocaine or ethanol taking is the predominantly reported effect of STN lesion (Baunez et al, 2005;Pelloux and Baunez, 2017;Pelloux et al, 2018).…”

Section: Stn-dbs Is Not Equivalent To Functional Inactivationmentioning

confidence: 87%

“…Results of STN lesion studies were more heterogeneous than with DBS, with increases (n = 6), decreases (n = 9), or no change in reward seeking (n = 6) being reported (Figures 3, 6). This heterogeneity cannot be completely explained by the type of reward used; STN-lesions had heterogeneous effects on responding for sucrose and food Robbins, 1997, 1999a;Baunez et al, 2002Baunez et al, , 2005Winstanley et al, 2005;Bezzina et al, 2008;Lardeux and Baunez, 2008;Uslaner et al, 2008;Winter et al, 2008), as well as for addictive drugs (Baunez et al, 2005;Lardeux and Baunez, 2008;Uslaner et al, 2008;Pelloux and Baunez, 2017;Montanari et al, 2018;Pelloux et al, 2018).…”

Section: Stn-dbs Is Not Equivalent To Functional Inactivationmentioning

confidence: 99%

Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review

Vachez

Creed

2020

Front. Hum. Neurosci.

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Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for the motor symptoms of movement disorders including Parkinson's Disease (PD). Despite its therapeutic benefits, STN-DBS has been associated with adverse effects on mood and cognition. Specifically, apathy, which is defined as a loss of motivation, has been reported to emerge or to worsen following STN-DBS. However, it is often challenging to disentangle the effects of STN-DBS per se from concurrent reduction of dopamine replacement therapy, from underlying PD pathology or from disease progression. To this end, pre-clinical models allow for the dissociation of each of these factors, and to establish neural substrates underlying the emergence of motivational symptoms following STN-DBS. Here, we performed a systematic analysis of rodent studies assessing the effects of STN-DBS on reward seeking, reward motivation and reward consumption across a variety of behavioral paradigms. We find that STN-DBS decreases reward seeking in the majority of experiments, and we outline how design of the behavioral task and DBS parameters can influence experimental outcomes. While an early hypothesis posited that DBS acts as a “functional lesion,” an analysis of lesions and inhibition of the STN revealed no consistent pattern on reward-related behavior. Thus, we discuss alternative mechanisms that could contribute to the amotivational effects of STN-DBS. We also argue that optogenetic-assisted circuit dissection could yield important insight into the effects of the STN on motivated behavior in health and disease. Understanding the mechanisms underlying the effects of STN-DBS on motivated behavior-will be critical for optimizing the clinical application of STN-DBS.

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Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease

et al. 2020

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Background Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation. Indeed, despite its effectiveness for alleviating PD motor symptoms, its neuropsychiatric repercussions have not yet been fully uncovered. Because it can be alleviated by dopaminergic therapies, especially D2 and D3 dopaminergic receptor agonists, the commonest explanation proposed for apathy after subthalamic nucleus deep brain stimulation is a too‐strong reduction in dopaminergic treatments. The objective of this study was to determine whether subthalamic nucleus deep brain stimulation can induce apathetic behaviors, which remains an important matter of concern. We aimed to unambiguously address this question of the motivational effects of chronic subthalamic nucleus deep brain stimulation. Methods We longitudinally assessed the motivational effects of chronic subthalamic nucleus deep brain stimulation by using innovative wireless microstimulators, allowing continuous stimulation of the subthalamic nucleus in freely moving rats and a pharmacological therapeutic approach. Results We showed for the first time that subthalamic nucleus deep brain stimulation induces a motivational deficit in naive rats and intensifies those existing in a rodent model of PD neuropsychiatric symptoms. As reported from clinical studies, this loss of motivation was fully reversed by chronic treatment with pramipexole, a D2 and D3 dopaminergic receptor agonist. Conclusions Taken together, these data provide experimental evidence that chronic subthalamic nucleus deep brain stimulation by itself can induce loss of motivation, reminiscent of apathy, independently of the dopaminergic neurodegenerative process or reduction in dopamine replacement therapy, presumably reflecting a dopaminergic‐driven deficit. Therefore, our data help to clarify and reconcile conflicting clinical observations by highlighting some of the mechanisms of the neuropsychiatric side effects induced by chronic subthalamic nucleus deep brain stimulation. © 2020 International Parkinson and Movement Disorder Society

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Subthalamic nucleus mediates the modulation on cocaine self‐administration induced by ultrasonic vocalization playback in rats

Cited by 17 publications

References 49 publications

Social modulation of drug use and drug addiction

Social modulation of drug use and drug addiction

Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review

Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease

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