Subthalamic nucleus deep brain stimulation in isolated dystonia

Abstract

This study provides Class IV evidence that STN DBS decreases long-term dystonia severity in patients with medically refractory isolated dystonia.

Quality of life outcomes after deep brain stimulation in dystonia: A systematic review

“…Pain is known to be one of the major determinants of HRQoL [2,74]. Bodily pain of SF-36 showed significant improvement in most studies [4,5,10,31,38,[40][41][42][43]45,47,73], which was consistent with the outcomes assessed with the scales specific to pain problems [5,34,38,39,75,76]. The general health scale of the SF-36 also significantly improved, suggesting that the patients' overall life satisfaction improved after DBS surgery [4,5,31,[41][42][43]45,72].…”

“…Most studies reported motor improvement according to the BFMDRS-M after bilateral STN DBS with a range between 40% and 80% similar to the outcomes of GPi DBS [40][41][42][43][44][45][46]. In a prospective study on 20 isolated dystonia patients with prominent cervical involvement, dystonia symptoms improved at 3 years by 70% and 67% according to BFMDRS-M and TWSTRS, respectively [40].…”

“…Most articles on inherited or idiopathic isolated dystonia patients reported significant improvement in physical QoL (physical functioning, role physical, bodily pain, and general health) [4,5,10,31,36,[40][41][42][43]45,47,72,73]. The physical functioning and role physical domains of SF-36 assess physical disability similar to BFMDRS-D, and TWSTRS disability scores.…”

Dystonia: diagnosis and management

“…The subthalamic nucleus (STN) has recently been proposed as a potential DBS target, alternative to GPi in patients with dystonia. A 3‐year follow‐up study provided class IV evidence that STN DBS decreases long‐term severity in patients with medically refractory isolated dystonia .…”

Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia

“…Ostrem et al 3 found STN DBS improved CD symptoms by greater than 50% when followed for 36 months after surgery; however, the range of clinical improvement was wide (30%–80%) and the underlying physiological changes were not examined.…”