Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia

Zisook, Sidney; Montross, Lori P.; Kasckow, John; Mohamed, Somaia; Palmer, Barton W.; Patterson, Thomas L.; Golshan, Shahrokh; Fellows, Ian E.; Lehman, David H.; Solorzano, Ellen

doi:10.1097/jgp.0b013e3180a725ec

Cited by 34 publications

(19 citation statements)

References 41 publications

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“…Existing studies suggest that SubD is associated with both threshold and subthreshold anxiety disorders (Kvaal et al, 2008; Palmer et al, 1997) in older adults—Geisselmann et al (2001) reported that 32% of older adults with SSD experienced significant anxiety symptoms (though not specifically DSM disorders). SubD is also prevalent among older persons with schizophrenia (Zisook et al, 2007; Diwan et al, 2007). While.a comprehensive review of comorbidity of SubD and sunsyndromal anxiety or other psychiatric conditions is beyond the scope of this work, we believe that an exploration of the course of illness and outcomes associated with psychiatric cormorbidity is warranted.…”

Section: Discussionmentioning

confidence: 99%

A tune in “a minor” can “b major”: A review of epidemiology, illness course, and public health implications of subthreshold depression in older adults

Meeks

Vahia

Lavretsky

et al. 2011

Journal of Affective Disorders

486

371

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BACKGROUND With emphasis on dimensional aspects of psychopathology in development of the upcoming DSM-V, we systematically review data on epidemiology, illness course, risk factors for, and consequences of late-life depressive syndromes not meeting DSM-IV-TR criteria for major depression or dysthymia. We termed these syndromes subthreshold depression, including minor depression and subsyndromal depression. METHODS We searched PubMed (1980–Jan 2010) using the terms: subsyndromal depression, subthreshold depression, and minor depression in combination with elderly, geriatric, older adult, and late-life. Data were extracted from 181 studies of late-life subthreshold depression. RESULTS In older adults subthreshold depression was generally at least 2–3 times more prevalent (median community point prevalence 9.8%) than major depression. Prevalence of subthreshold depression was lower in community settings versus primary care and highest in long-term care settings. Approximately 8–10% of older persons with subthreshold depression developed major depression per year. The course of late-life subthreshold depression was more favorable than that of late-life major depression, but far from benign, with a median remission rate to non-depressed status of only 27% after ≥1 year. Prominent risk factors included female gender, medical burden, disability, and low social support; consequences included increased disability, greater healthcare utilization, and increased suicidal ideation. LIMITATIONS Heterogeneity of the data, especially related to definitions of subthreshold depression limit our ability to conduct meta-analysis. CONCLUSIONS The high prevalence and associated adverse health outcomes of late-life subthreshold depression indicate the major public health significance of this condition and suggest a need for further research on its neurobiology and treatment. Such efforts could potentially lead to prevention of considerable morbidity for the growing number of older adults.

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Section: Discussionmentioning

confidence: 99%

A tune in “a minor” can “b major”: A review of epidemiology, illness course, and public health implications of subthreshold depression in older adults

Meeks

Vahia

Lavretsky

et al. 2011

Journal of Affective Disorders

486

371

View full text Add to dashboard Cite

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“…It is not uncommon for individuals to develop post-psychotic depression as they develop insight into their illness and become demoralized by the discrepancy between their developmental trajectory and that of their peers [24]. Depression [25] and substance use disorders are commonly comorbid with schizophrenia [26,27]. The suicide rate in schizophrenia is 5.6 % [28], which, although lower than previously cited rates, is still significant.…”

Section: Clinical Presentationmentioning

confidence: 98%

Cognitive Behavioral Approaches for Schizophrenia and Other Psychotic Disorders

Marcus

Cather

2016

The Massachusetts General Hospital Handbook of Cognitive Behavioral Therapy

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“…On retrouve également une association entre akathisie sévère et dépression [13]. Les patients souffrant de troubles dépressifs sont plus traités par antipsychotiques atypiques ou par association d'antipsychotiques typiques et atypiques [13].…”

Section: Comparaison Avec Les Sujets D'âge Moyen Souffrant De Schizopunclassified

“…Mais, il existe un recouvrement possible avec les symptômes négatifs [12]. D'autre part, les patients souffrant de troubles schizo-affectifs ont été inclus dans certaines études, ce qui peut biaiser les résultats [4,13,14].…”

Section: Comparaison Avec Les Sujets D'âge Moyen Souffrant De Schizopunclassified

Schizophrénie, vieillissement et dépression

Ortega¹,

Bazile²,

Pontonnier³

et al. 2009

Annales Médico-psychologiques, revue psychiatrique

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A c c e p t e d M a n u s c r i p t The authors thus give a progress report on the question of depression in schizophrenic old patients. The six descriptive studies studied concerning the depressive symptoms at the schizophrenic old patient show that the frequency of the depressive disorders seems more important in this group of patient than in the general population of the same age. The depressive symptoms seem to be more often associated with the positive symptoms than with the negative symptoms. It is not found of association in the studies between depressive symptoms and antipsychotic dose, negative and neurologic symptoms, and deterioration of neurocognitive functioning. We find in this category of patients some of depression's predictive variables of the old general population. The coming out of depressive disorders seems to be associated with severity of schizophrenia's disease and with bad everyday functioning.

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Subsyndromal Depressive Symptoms in Middle-Aged and Older Persons with Schizophrenia

Cited by 34 publications

References 41 publications

A tune in “a minor” can “b major”: A review of epidemiology, illness course, and public health implications of subthreshold depression in older adults

A tune in “a minor” can “b major”: A review of epidemiology, illness course, and public health implications of subthreshold depression in older adults

Cognitive Behavioral Approaches for Schizophrenia and Other Psychotic Disorders

Schizophrénie, vieillissement et dépression

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