Substratos de desenvolvimento larval de Drosophilidae (Diptera) na reserva florestal do Instituto de Biociências da USP

Rampasso, Augusto Santos

doi:10.11606/d.41.2019.tde-02082019-084917

Cited by 1 publication

(1 citation statement)

References 94 publications

(162 reference statements)

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“…[24] The sample of E. vannamei, under number (#198), is deposited at the ascidian collection of the Departamento de Engenharia de Pesca, Universidade Federal do Ceará. [25] The bacterial (BRA-006) was identified as the Actinomycete Micromonospora sp. based on 16S rRNA sequencing, available at (http:// www.ncbi.nlm.nih.gov/genbank) under the access number (ON286968).…”

Section: Bacterial Materialsmentioning

confidence: 99%

Further Polycyclic Quinones of Micromonospora sp

Silva de Freitas Cesário,

das Chagas Lima Pinto,

Marques Canuto

et al. 2024

Chemistry & Biodiversity

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The crude acetone extract of a marine Micromonospora sp. strain associated with Eudistoma vannnamei was fractioned with hexane and ethyl acetate. The crude extract and both soluble fractions were assayed against several bacteria strains. The new polycyclic quinones 12‐hydroxy‐9‐propyltetracene‐6,1‐dione (1), 5,12‐dihydroxy‐4‐methoxy‐9‐propyltetracene‐5,12‐dione (2), and 4,6‐dihydroxy‐3‐methoxycarbonyl‐ methyl‐6a‐(oxobutyl)‐5,12‐anthraquinone (3), along with the known 4,6‐dihydroxy‐3‐methoxycarbonyl‐methyl‐6a‐(oxo‐3‐methyl‐butyl)‐5,12‐anthraquinone (4) and 4,6‐dihydroxy‐3‐methoxycarbonyl‐methyl‐6a‐(oxopentyl)‐5,12‐anthraquinone (5) were isolated from the hexane‐soluble fraction, while from the active ethyl acetate fraction were isolated the known 4,6,11‐trihydroxy‐9‐propyltetracene‐5,12‐dione (6), 4‐methoxy‐9‐propyltetracene‐6,11‐dione (7), 7,8,9,10‐tetrahydro‐9‐hydroxy‐4‐methoxy‐9‐propyltetracene‐6,11‐dione (8), and 10b‐carbomethoxy‐7,8,9,10‐tetrahydro‐4,6,7a,9a,11‐pentahydroxy‐9‐propyltetracene‐5,12‐dione (9). The structures of the new compounds were established by interpretation of HRMS and NMR techniques. A study of molecular docking was performed with the compounds from the active ethyl acetate fraction to correlate tentatively with the antimicrobial activity. Molecular docking, RMSD, RMSF, and MM‐GBSA evaluations were performed to investigate the inhibitory activity of 6‐8 against the protein PDB‐codex 1MWT, being considered a promising target for studying drug development responsible for inhibiting replication of Staphylococcus aureus. Penicillin G was used as the standard inhibitory. Anthracyclinones 6‐8 were the best hydrolase inhibitor with affinity energy ‐8.1 to ‐7.9 kcal/mol compared to penicillin G, which presented ‐6.9 kcal/mol.

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Section: Bacterial Materialsmentioning

confidence: 99%