Substrate Selectivity Check of the Ergothioneine Transporter

Tschirka, Julia; Kreisor, Madlen; Betz, Janina; Gründemann, Dirk

doi:10.1124/dmd.118.080440

Cited by 57 publications

(64 citation statements)

References 29 publications

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“…ET, a thione-derivative of histidine (reviewed in [15]) is an unique putative antioxidant and cytoprotective compound [15][16][17][18]. While humans are unable to synthesize ET, it can be readily absorbed from diet (main source is mushrooms) and actively accumulated in the body and the brain via a specific transporter, OCTN1 [19][20][21][22]. Our recent study in elderly Singaporeans revealed that plasma levels of ET in participants with MCI were significantly lower than age-matched healthy individuals [23], leading us to believe that a deficiency in ET may be a risk factor for neurodegeneration, and increase ET intake through mushroom consumption might possibly promote cognitive health.…”

Section: Discussionmentioning

confidence: 99%

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Feng

Cheah

et al. 2019

JAD

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We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0.23-0.78, p = 0.006) and this association was independent of age, gender, education, cigarette smoking, alcohol consumption, hypertension, diabetes, heart disease, stroke, physical activities, and social activities. Our cross-sectional data support the potential role of mushrooms and their bioactive compounds in delaying neurodegeneration.

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Section: Discussionmentioning

confidence: 99%

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Feng

Cheah

et al. 2019

JAD

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“…As a further illustration of the widespread distribution of ET and possibly the essentiality of this compound to humans (as suggested by the presence of a transporter that appears largely specific for ET ), we have recently identified the presence of ET in human breast milk (with ET concentrations ranging from 5 to 150 n m ; paper in preparation). ET can also be found in cow and goat's milk (with mean concentrations ~ 13 n m and ~ 9 n m , respectively) and a range of infant formulas (with a mean concentration ~ 9 n m ).…”

Section: Ergothioneine and The Mother–baby Axismentioning

confidence: 91%

“…Interestingly, some foods have large variations in the levels of ET, for example, asparagus, which we believe to be attributed to possible symbiotic relationships of these plants with soil fungi or bacteria, or pre‐ or postharvest fungal contamination (Table ). Dietary ET in animals (including humans) is absorbed by means of an intestinal transporter, OCTN1, that has a high degree of specificity . The same transporter then distributes ET to most or all body tissues: excretion from the body is slow and administered ET is highly retained in human and other animal body tissues and red blood cells .…”

Section: Ergothioneine a Natural “Antioxidant”?mentioning

confidence: 99%

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

2018

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Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties in vitro and there is evidence that the body may concentrate it at sites of tissue injury by raising OCTN1 levels. Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression. This brief Review explores the possible roles of ergothioneine in human health and disease.

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“…The OCTN1(SLC22A4) transporter may import in the liver, kidney, intestine and other organs a variety of soluble compounds with diverse chemical structures (Drenberg et al ., ). This observation is controversial as OCTN1 appears mainly to transport ergothioneine (Tschirka et al ., ). However, OCTN1 may still be highly relevant.…”

Section: The Taming Of Fire and Its Consequencesmentioning

confidence: 97%

Bacteria in the ageing gut: did the taming of fire promote a long human lifespan?

Danchin

2018

Environmental Microbiology

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Unique among animals as they evolved towards Homo sapiens, hominins progressively cooked their food on a routine basis. Cooked products are characterized by singular chemical compounds, derived from the pervasive Maillard reaction. This same reaction is omnipresent in normal metabolism involving carbonyls and amines, and its products accumulate with age. The gut microbiota acts as a first line of defence against the toxicity of cooked Maillard compounds, that also selectively shape the microbial flora, letting specific metabolites to reach the blood stream. Positive selection of metabolic functions allowed the body of hominins who tamed fire to use and dispose of these age-related compounds. I propose here that, as a hopeful accidental consequence, this resulted in extending human lifespan far beyond that of our great ape cousins. The limited data exploring the role of taming fire on the human genetic setup and on its microbiota is discussed in relation with ageing.

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Substrate Selectivity Check of the Ergothioneine Transporter

Cited by 57 publications

References 29 publications

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Bacteria in the ageing gut: did the taming of fire promote a long human lifespan?

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