Substrate regulation of elymoclavine formation by some saccharides

Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate

“…The industrial synthesis of the most important ergot alkaloids available on the market (i.e., cabergoline, nicergoline, metergoline, methylergonovine, and pergolide mesylate) starts from raw materials obtained by fermentation. Both lysergic acid 2 and elymoclavine 3 already have the basic four-member ring architecture and the correct configuration at C-5 and C-8 and are produced by fermentation of mutants of Claviceps paspali and Claviceps purpurea, respectively (Scheme ). The diastereoselective hydrogenation catalysed by Raney nickel (>95%) affords the corresponding dihydroderivatives, 4 and 5 , with complete control of the C-10 configuration .…”

Isolation and characterization of an alkaloid‐blocked mutant of Claviceps paspali

“…The spectra of saprophytically synthesized ergot alkaloids may be changed either by mutation (STRNADOVA 1964, 1967, KOBEL and SANGLIER 1973, G R~G E R 1979 or by changing the culture conditions (KREN et al 1987, BREUEL et af. 1982.…”