“…There are many indirect evidences that indicate an association between Src kinases and hematologic malignancies, as summarized previously (Li, 2005). (Burnett et al, 1991;Ernould, Ferry, Barret, Genton, & Boutin, 1994;Fischer et al, 1989;Lynch et al, 1993;Myers et al, 1995;Tilbrook et al, 2001;Uckun et al, 1995;Waki et al, 1994;Willman et al, 1991;Yamaguchi et al, 1997). Direct evidence for the roles of Src kinases in leukaemogenesis is inadequate; recently, we provided convincing evidence that Src kinases are required for proliferation of leukaemic cells in mice with ALL (Hu et al, 2004;Hu et al, 2006).…”