Substrate Controlled [3+3] Relay Catalytic Cyclization of α‐(3‐Isoindolinonyl) Propargylic Alcohols with 5‐Aminoisoxazoles
Wenzhe Li,
Min Gao,
Min Li
et al.
Abstract:Two different skeletons have been constructed by cyclization of α‐(3‐isoindolinonyl) propargylic alcohols with 5‐aminoisoxazoles bearing different N‐substituents under the relay catalysis of Brønsted acid and Lewis acid. This method provided spiro‐isoindolinone‐dihydropyridines with moderate to high yields (up to 99%) as well as isoxazolo[4,5‐b]pyridines in moderate to good yields (up to 86%). The structures of two products were determined by X‐ray crystal structural analyses. Moreover, fluorescence testing pr… Show more
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