Li Chen, Xuanjun Ai, Athina G. Portaliou, Conceicao A.S.A. Minetti, David P. Remeta, Anastassios Economou, Charalampos G. Kalodimos
Targeting of type III secretion proteins at the injectisome is an important process in bacterial virulence. Nevertheless, how the injectisome specifically recognizes TTS substrates among all bacterial proteins is unknown. A TTS peripheral membrane ATPase protein located at the base of the injectisome has been implicated in the targeting process. We have investigated the targeting of the EspA filament protein and its cognate chaperone CesAB to the EscN ATPase of the enteropathogenic E. coli (EPEC). We …
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