Substitution with Lopinavir/Ritonavir Improves Patient-Reported Outcomes Including Quality of Life in Patients Who Were Intolerant to Their Antiretroviral Therapy

Patient-reported outcomes in daily clinical practise in HIV outpatient care

“…In the context of HIV, PRO systems have previously been investigated to assess health-related quality of life and selfreported adherence (Marrone et al, 2016;Schnall et al, 2017;Sprinz et al, 2006), but it appears that this is the first reported study to evaluate the actual implementation of PROs in outpatient care for HIV-infected individuals. Several studies have emphasized the potential for using PROs in clinical practise in the context of HIV infection (Edwards et al, 2016;Marcellin et al, 2012).…”

Formulation preference, tolerability and quality of life assessment following a switch from lopinavir/ritonavir soft gel capsule to tablet in human immunodeficiency virus-infected patients

“…The MOS-HIV Health Survey contains 35 items that cover 11 dimensions of health including physical functioning, pain, social functioning, emotional well-being, energy/fatigue, overall QoL, and health transition. Patient responses were scored according to the published scoring algorithm, which ranges from 0 to 100, with higher scores indicating better health and well-being [ 13 , 14 ]. Mental Health Summary (MHS) and Physical Health Summary (PHS) scores were calculated from the MOS-HIV scale using a method that transforms the scores to a standardized scale with a mean of 50 and a standard deviation of 10 for that particular population.…”

“…The Augmented Symptoms Distress Module (ASDM) is a measurement of the presence of common symptoms related to HIV infection, and the extent to which they cause distress to the patient. The ASDM included 22 items that were scored on a scale from 0 to 4, a higher score reflecting the presence of more symptoms and/or a greater degree of symptom-related distress [ 14 ].…”

“…The Center for Epidemiological Studies-Depression (CES-D) instrument is a depression questionnaire consisting of 20 items with 1-week patient recall [ 14 , 15 ]. Components of the questionnaire include depressed mood, feelings of guilt and worthlessness, feelings of hopelessness, loss of appetite, and sleep disturbance.…”

Letter to the Editor: Emergence of Protease Resistance During Simplification Therapy with Lopinavir/Ritonavir Alone

“…At that time, his HIV viral load was 34,000 copies/mL in plasma. After almost 2 years (June 2002), although his viral load was undetectable throughout this period, he was enrolled in PLATO study 10 (switch for LPV/r) due to central nervous system adverse events and gynecomastia attributable to efavirenz. The dose of LPV/r was increased by one third in the first week of treatment due to the pharmacokinetic drug interaction between LPV/r and efavirenz.…”