Substitution mit Mineralstoffen und Spurenelementen Eisen, Zink und Selen

Anemia is the most prevalent extraintestinal complication of IBD. It can affect quality of life and ability to work, and can also increase the hospitalization rate in patients with IBD. Although the causes of anemia in IBD are multifactorial, iron deficiency anemia (IDA) is the most common. Assessment of the iron status of patients who have a condition associated with inflammation, such as IBD, by using common biochemical values is insufficient. However, new indices of iron metabolism (for instance ferritin:transferrin receptor ratio, reticulocyte hemoglobin content or percentage of hypochromic red blood cells) may help to improve the assessment of iron status in patients with IBD. The treatment of IDA traditionally involves oral iron supplementation. However, because of extensive gastrointestinal adverse effects, and data showing that the use of oral iron in IBD may be associated with disease exacerbation, current guidelines suggest that iron supplementation in IBD should be administered intravenously. This Review provides an overview of iron homeostasis in health before discussing diagnostic and therapeutic strategies for IDA in patients with IBD.

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Diagnosis and management of iron deficiency anemia in patients with IBD

Stein

Hartmann

Dignaß

2010

Nat Rev Gastroenterol Hepatol

244

219

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Pathophysiologisch-orientierte Diagnostik und Therapie der Eisenmangelanämie bei chronisch entzündlichen Darmerkrankungen

Stein¹,

Hartmann²,

Cordes³

et al. 2009

Z Gastroenterol

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Anaemia is the most frequent extraenteric complication of inflammatory bowel disease (IBD, Crohn's disease and ulcerative colitis). A disabling complication of IBD, anaemia worsens the patient's general condition and quality of life, and increases hospitalization rates. The main types of anemia in IBD are iron deficiency anemia and anemia of chronic disease. The combination of the serum transferrin receptor with ferritin concentrations and inflammatory markers allows a reliable assessment of the iron status. Iron deficiency is usually treated with oral iron supplements. However, it is less effective in IBD and may lead to an increased inflammatory activity through the generation of reactive oxygen species. A systematic review of anemia in IBD, its pathogenetic features, epidemiology, diagnosis and therapy based on the evidence from recent studies will be the focus of this article.

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Substitution mit Mineralstoffen und Spurenelementen Eisen, Zink und Selen

Abstract: Eisen 10-15 mg/TagSelen 20-100 µg/Tag Zink m: 15 mg/Tag w: 12 mg/Tag, 22 mg/Tag in der Stillzeit Abb.5 ᭣ Perinasal schuppende, scharf begrenzte ekzematöse Hautveränderungen bei Zinkmangel nach 6-wöchiger parenteraler Ernährung. (Aus [18])

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Diagnosis and management of iron deficiency anemia in patients with IBD

Diagnosis and management of iron deficiency anemia in patients with IBD

Pathophysiologisch-orientierte Diagnostik und Therapie der Eisenmangelanämie bei chronisch entzündlichen Darmerkrankungen

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