Substitution Kinetics, Albumin and Transferrin Affinities, and Hypoxia All Affect the Biological Activities of Anticancer Vanadium(V) Complexes
Aviva Levina,
Canan Uslan,
Heide Murakami
et al.
Abstract:Limited stability of most transition-metal complexes in biological media has hampered their medicinal applications but also created a potential for novel cancer treatments, such as intratumoral injections of cytotoxic but short-lived anticancer drugs. Two related V(V) complexes, [VO(Hshed)(dtb)] ( 1) and [VO(Hshed)(cat)] ( 2), where H 2 shed = N-(salicylideneaminato)-N′-(2-hydroxyethyl)-1,2-ethanediamine, H 2 dtb = 3,5-di-tert-butylcatechol, and H 2 cat = 1,2-catechol, decomposed within minutes in cell culture… Show more
A series of non-innocent halogen substituted Schiff base vanadium catecholate added different electron donating and withdrawing substituents on the catecholate to investigate the electronic effects on the properties of this...
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