Substituting gelatine with Pluronic F-127 matrix in 3D polymer gel dosimeters can improve nuclear magnetic resonance, thermal and optical properties

Jaszczak, Malwina; Wach, Radosław A.; Maras, Piotr; Dudek, Mariusz; Kozicki, Marek

doi:10.1088/1361-6560/aad9d5

Cited by 41 publications

(32 citation statements)

References 57 publications

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“…Radiochromic samples were composed of distilled water, poly(ethylene oxide)– block –poly(propylene oxide)– block –poly(ethylene oxide) (Pluronic F–127, Sigma-Aldrich, Saint Louis, MO, USA) as a gel matrix and nitro blue tetrazolium chloride (M = 817.64 g/mol) (NBT, Roth, Karlsruhe, Germany) as a radiation-sensitive compound. The use of Pluronic F–127, provides a colorless and transparent hydrogel matrix that does not change color after UV irradiation [ 34 , 35 , 36 ]. Moreover, Pluronic F–127 is approved by the US Food and Drug Administration (FDA) as a nontoxic copolymer [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Study of NBT–Pluronic F–127 Gels as 1D UV Radiation Dosimeters for Measurement of Artificial Light Sources

2022

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This work reports on radiochromic dosimeters for 1D UV light measurements. The dosimeter is composed of a 25% Pluronic F–127 that forms a physical gel matrix and nitro blue tetrazolium chloride (NBT) as a radiation-sensitive compound. This dosimeter was exposed to UVA, UVB and UVC radiation, and the radiochromic reactions were followed with reflectance spectrophotometry including changes in light reflectance and color coordinates in the CIELAB color system. The exposition of dosimeters to all UV radiation caused color changes from pale yellow to dark violet, and its intensity increased with increasing absorbed dose. The effects of NBT concentration and UV radiation type on the dose–response of the dosimeters were also examined. The results obtained reveal that the dosimeters are the least sensitive to irradiation with UVC and the most sensitive to irradiation with UVB (e.g., dosimeter with 2 g/dm3 of NBT was characterized by the following parameters: the threshold dose 0.1 J/cm2; the dose sensitivity −5.97 ± 0.69 cm2/J; the linear dose range 0.1–2.5 J/cm2; the dynamic dose range was equal to 0.1–3 J/cm2). The results obtained reveal that the NBT–Pluronic F–127 dosimeters can be potentially useful as 1D sensors for artificial UV radiation sources measurements.

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Section: Methodsmentioning

confidence: 99%

Study of NBT–Pluronic F–127 Gels as 1D UV Radiation Dosimeters for Measurement of Artificial Light Sources

2022

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“…Various studies have analyzed the MRI response of polymer gels for possible application in radiotherapy dose mapping ([ 58 , 63 ] and references therein). In particular, polymer gels have been investigated for dosimetry in conformal therapy, IMRT, IMAT, IGRT, VMAT and tomotherapy [ 55 , 70 , 83 , 88 , 102 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], small photon fields [ 136 , 137 , 138 ], stereotactic radiosurgery [ 55 , 139 , 140 , 141 , 142 ], 60-cobalt source [ 143 , 144 ], brachytherapy [ 55 , 85 , 92 , 145 , ...…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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“…Thereafter, the dispersed 20 ml of Curcumin-loaded microemulsion and 0.2% methylparaben and 0.1 % propyl paraben as preservative in above solution with continuous mixing at room temperature. The dispersion was neutralized by using 50% (w/w) triethanolamine or NaOH to obtain the emulgel and prepared emulgel kept in the freeze for 2 h to get homogenous and smooth emulgel [28].…”

Section: Formulation Of Curcumin-loaded Emulgelmentioning

confidence: 99%

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

Bairagi

Patel

2021

Int J Curr Pharm Sci

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Objective: The main causative agent of vaginal candidiasis is Candida albicans and it develops resistance against several synthetic antifungal drugs and it has a high rate of infection in women. According to WHO report, around 75% of women are infected by Candida albicans and 50 % are infected a second time by Candida albicans. Therefore, we choose Curcumin an antifungal agent that had reported antifungal properties against the various fungal species. The Curcumin-containing emulgel based microemulsion system was prepared for greater retention time and penetration across the vaginal mucosa. Methods: The screening of oil phase, surfactant, and cosurfactant for microemulsion formulation was selected based on the solubility study and followed by the construction of the pseudoternary phase diagram. The oil phase, surfactant and co-surfactant are selected from the pseudoternary phase diagram for the formulation of a stable microemulsion. The prepared Curcumin-loaded microemulsion was characterized by globule size, polydispersity index, Zeta potential, accelerated stability study, drug content, percent transmittance and antifungal assay by broth microdilution technique. The formulated microemulsion was converted into a vaginal emulgel by using Pluronic@F127. The formulated curcumin-loaded emulgel was characterized by different evaluation parameters and antifungal study by agar well diffusion method. Results: The result showed that the average globule size of emulgel was 286.3 nm, polydispersity index was 0.241, Zeta potential was+19.20 mv, conductivity was 0.0390 mS/cm, and drug content was found to be 95.58%. The texture of formulated emulgel was found to be soft and smooth, with shear-thinning, pseudoplastic behavior, and easily spreadable. The in vitro permeability study of emulgel shows slow and complete release of curcumin in 10 h. The microemulsion and developed emulgel showed promising antifungal activity against Candida albicans. Conclusion: The developed curcumin-loaded emulgel showed promising antifungal activity against Candida albicans as compared to the Fluconazole as an standard antifungal antibiotic. Our formulated Curcumin-containing emulgel can be a potential alternative as compared to the conventional dosage form for the treatment of vaginal candidiasis.

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Substituting gelatine with Pluronic F-127 matrix in 3D polymer gel dosimeters can improve nuclear magnetic resonance, thermal and optical properties

Cited by 41 publications

References 57 publications

Study of NBT–Pluronic F–127 Gels as 1D UV Radiation Dosimeters for Measurement of Artificial Light Sources

Study of NBT–Pluronic F–127 Gels as 1D UV Radiation Dosimeters for Measurement of Artificial Light Sources

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

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