Substituted Tetralins IV: Synthesis and Stereochemistry of 4,4-Disubstituted 1,2,3,4-Tetrahydro-2-naphthoic Acids

Substituted Tetralins VI: Tentative Assignment of Absolute Stereochemistry of 1-Methyl-1-phenyl-1,2,3,4-tetrahydro-3-naphthoic Acid and N,N,1-Trimethyl-1-phenyl-1,2,3,4-tetrahydro-3-naphthylamine Isomers

“…Keyphrases Permeation, cutaneous-scopolamine, mathematical model for pharmacokinetics in human skin Scopolamine-cutaneous permeation, mathematical model for pharmacokinetics in human skin Pharmacokinetics-cutaneous permeation of scopolamine, mathematical model for human skin 0 Dosage forms-transdermal therapeutic system for scopolamine delivery, mathematical model for pharmacokinetics Anticholinergics-scopolamine, cutaneous permeation, mathematical model for pharmacokinetics in human skin Considerable attention has been focused on drug permeation through skin in uitro (1)(2)(3). The principal resistance to drug permeation through intact human skin resides within the stratum corneum, which is comprised of dead, partially desiccated, keratinized epidermal cells (3).…”

“…This cyclization previously was employed to assign the relative stereochemistry of racemic IIa and IIb (2). This cyclization previously was employed to assign the relative stereochemistry of racemic IIa and IIb (2).…”

Pharmacokinetics of Drug Permeation through Human Skin

“…Considerable attention has been focused on drug permeation through skin in uitro (1)(2)(3). The principal resistance to drug permeation through intact human skin resides within the stratum corneum, which is comprised of dead, partially desiccated, keratinized epidermal cells (3).…”