Substituted methoxybenzyl-sulfonyl- 1H -benzo[d]imidazoles evaluated as effective H + /K + -ATPase inhibitors and anti-ulcer therapeutics

Rajesh, R; Sivakumar, A.; Ramasubbu, Chandrasekaran; Nagaraju, N.

doi:10.1016/j.ejmech.2017.08.001

Cited by 16 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 4-methoxy phenyl piperazine substituted benzimidazole derivative (183) appeared to be the most effective agent (Patil et al, 2012). Chang et al (Chang et al, 2012) (Rajesh et al, 2017). Finally, some new benzimidazole-pyrazole hybrids were evaluated for in vivo anti ulcerogenic activity using ethanol-induced gastric ulcer model in Albino rats.…”

Section: Antiulcer Activitymentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

View full text Add to dashboard Cite

Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent. Due to their isostructural pharmacophore of naturally occurring active biomolecules, benzimidazole derivatives have significant importance as chemotherapeutic agents in diverse clinical conditions. Researchers have synthesized plenty of benzimidazole derivatives in the last decades, amidst a large share of these compounds exerted excellent bioactivity against many ailments with outstanding bioavailability, safety, and stability profiles. In this comprehensive review, we have summarized the bioactivity of the benzimidazole derivatives reported in recent literature (2012–2021) with their available structure-activity relationship. Compounds bearing benzimidazole nucleus possess broad-spectrum pharmacological properties ranging from common antibacterial effects to the world’s most virulent diseases. Several promising therapeutic candidates are undergoing human trials, and some of these are going to be approved for clinical use. However, notable challenges, such as drug resistance, costly and tedious synthetic methods, little structural information of receptors, lack of advanced software, and so on, are still viable to be overcome for further research.

show abstract

Section: Antiulcer Activitymentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The gel isolated from the seeds of fenugreek seeds has significant anti gastric ulcer activity, which is due to its inhibitory effect on gastric acid secretion and gastric mucosal glycoproteins. In addition, fenugreek seed extracts can effectively reduce mucosal damage by improving the antioxidant capacity of gastric mucosa and preventing lipid peroxidation induced by alcohol [19] .…”

Section: Othermentioning

confidence: 99%

Analysis of the Chemistry, Pharmacology and Application Characteristics of Fenugreek

Chu¹,

Qiao²,

Miao³

2019

dtssehs

View full text Add to dashboard Cite

Fenugreek is the seed of leguminous. Steroidal saponins, flavonoids, alkaloids, coumarins and other chemical constituents have been isolated from it. It has hypoglycemic, anti lipid, anti-tumor, anti ulcer and other biological activities. In this paper, the chemical constituents, pharmacological action and application of fenugreek were summarized, so as to lay a theoretical foundation for the efficient development and utilization of fenugreek plant resources.

show abstract

“…Their flexibility in electron exchange between various electron donor and acceptors between the receptors making benzimidazoles as a chief inhibitors based therapeutic agents. They are inhibitors of kinases [9,10], cyclooxygenase [11], H + , K + ATPase/proton pump [12,13], acetylcholinesterase [14] and protein kinase CK2 [15], etc.…”

Section: Introductionmentioning

confidence: 99%

“…Redisep silica gel columns used for flash chromatography and mobile phase solvents as indicated in procedures. 1 H and 13 C NMR spectra were recorded in Bruker-300MHz instrument while LC-MS was recorded on Agilent instruments.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Molecular Drug Validations of 1H-Benzo[d]imidazol-2-amine Derivatives: Molecular Docking and its Biological Activities

Ashok

Shivananda

2019

Asian J. Chem.

Self Cite

View full text Add to dashboard Cite

Molecular adaptation of small molecules that are targeted as therapeutic agents is a most anticipated one in drug designing and development. In the present approach, a family of substituted 1H-benzo[d]imidazol-2-amine derivatives (5a-d and 6a-e) were effectively synthesised and testified for their molecular adaptations in order to develop them as novel medications against oxidation, inflammation and inflammation associated cancer types by means of in silico and in vitro assessments. Chronic inflammation, regardless of infectious agents, plays a vital role in various cancer development. Moreover, hypoxia-inflammation-cancer are highly associated together. Hydrogen peroxide free-radical scavenging, HRBC membrane stabilization assay and cell viability test by MTT assay (macrophage) were executed to establish antioxidant, anti-inflammatory and anticancer properties of these compounds. As the prostaglandin-endoperoxide synthase 2 is highly involved in inflammation and cancer development respectively, molecular docking was executed on the corresponding X-ray crystallographic models (PDB structures).

show abstract

Substituted methoxybenzyl-sulfonyl- 1H -benzo[d]imidazoles evaluated as effective H + /K + -ATPase inhibitors and anti-ulcer therapeutics

Cited by 16 publications

References 32 publications

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Analysis of the Chemistry, Pharmacology and Application Characteristics of Fenugreek

Synthesis and Molecular Drug Validations of 1H-Benzo[d]imidazol-2-amine Derivatives: Molecular Docking and its Biological Activities

Contact Info

Product

Resources

About