Substituted Imidazonaphthyridine Derivatives. I. C19H14F3N3, C18H10F5N3, C18H11ClF3N3 and C18H11BrF3N3

Substituted Imidazonaphthyridine Derivatives. II. C19H17N3O and C24H19N3O

“…We continue our reports of the crystal structures of imidazonaphthyridine compounds (Fun et al, 1996;Sivakumar et al, 1996) with those of three 1,2,6,8-tetrasubstituted imidazonaphthyridine compounds, (VII), (VIII) and (IX). All three compounds were prepared by the Mannich reaction (Chua & Jackson, 1995).…”

“…In (VII), (IXA) and (IXB), the orientation of the diethylaminomethyl group is favourable for intramolecular C12--H12--.N4 hydrogen bonding whereas in (VIII) the orientation of this group is entirely different and an intermolecular C--H.. In 2,6,8-trisubstituted imidazonaphthyridine derivatives, the molecules readily form dimers through C2--H2...N1 bonds (Fun et al, 1996; …”

“…From our studies on 2,6,8-substituted imidazo[1,2-a]l,8-naphthyridine derivatives, we observe that only (VI) is monoclinic, the other compound being triclinic (space group P1). The 8-methyl and 8-trifluoromethyl compounds, (I)-(V) (Fun et al, 1996) have the same mode of packing which differs from that of the 8-phenyl compound (VI).…”

10-Methoxybenzo[g]imidazo[1,2-a][1,8]naphthyridine-4-carbonitrile

“…In addition, both methoxy and carbonitrile substituents attached to C(2) and C(11), respectively, are oriented in such a way that they both lay in heterocyle plane granting a nearly planar geometry to the entire molecule (RMS deviation of the all non-hydrogen atoms from mean plane is 0.044 Å). Bond distances and angles in the title compound are normal (Allen et al, 1987) and compare well with other imidazonaphtyridines derivatives (Fun et al, 1996;Sivakumar et al.1996a,b;Muthamizhchelvan et al, 2005a,b). (Table 1) forming a three dimensional polymeric structure ( Figure 2).…”