Substituted chromones as coronary vasodilators

Bariana, D. S.

doi:10.1021/jm00305a057

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Oriental Journal Of Chemistry1

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2014

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“…5 Compounds containing chromone moiety are synthetically versatile molecules with a reactive carbonyl group having considerable significance for their biological activities [6][7] and for their reactivity with nucleophiles, which allow the synthesis of a wide veriety of heterocycles. Chromones are reported to exhibit anti-inflammatory, 8 antimicrobial, [9][10] anticancer, 11 antiallergic 12 and coronary vasodialator 13 activity. Some chromones has potential HIV-integrase inhibition activity [14][15][16][17][18] .…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis, characterization and antimicrobial screening of some fluorinated chromones and chlorochromones

Jagadhani¹,

Kundalikar²,

Karale³

2014

Orient J Chem

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ABSTRACT4-Bromo-2-fluorobenzaldehyde when treated with substituted hydroxyacetophenones yields chalcones 3. These chalcones were cyclized using DMSO/I 2 gave the compound 2-(4-Bromo-2-fluorophenyl)-4H-chromen-4-one 4. Chalcones on treatment with DMSO/CuCl 2 yields 2-(4-bromo-2-fluorophenyl)-3-chloro-4H-chromen-4-one 5. The structures of compounds have been established on the basis of spectral data. These compounds were screened for their antimicrobial activities.

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Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis, characterization and antimicrobial screening of some fluorinated chromones and chlorochromones

Jagadhani¹,

Kundalikar²,

Karale³

2014

Orient J Chem

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“…3-(1H-Tetrazol-5-yl)chromones have been found to show very good antiallergic activity [2]. Substituted chromones have been found to have coronary vasodilatory activity [3]. (Piperidinylalkoxy) chromones have been reported to show antihistamine and antagonistic activity against leukotriene-D 4 [4].…”

Section: Introductionmentioning

confidence: 99%