Substitute, inexpensive diagnosis of H. pylori infection by infra-red(IR) spectrophotometer in 13C-urea breath test

Taniguchi, Yasuyuki; Kimura, Kyosuke; Satoh, Kazunori; Kawada, Hiroshi; Sohara, H.; Yamamoto, Hiroaki; Ido, Kentaro; Ogihara, Yuki; Goto, Yuta; Takatori, Keiko; Iida, Kazutada; Kajiwara, Masahiro

doi:10.1016/0016-5085(95)23601-5

Cited by 2 publications

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“…The infrared spectrophotometric analysis has been validated and has correlated well with mass spectrometric analysis in adults and children (32–35). The infrared spectrophotometer used in our study (Oridion Breath ID™ H. pylori Breath Test Kit, Israel) has been also validated in children (36).…”

Section: Methodsmentioning

confidence: 99%

Comparison of Invasive and Non‐Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children

Hino,

Eliakim,

Levine

et al. 2004

J. pediatr. gastroenterol. nutr.

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Background:There are few reports which the tests used for diagnosing Helicobacter pylori infection and monitoring its eradication in children.Study Aims:Prospective evaluation of invasive (gastric histology, rapid urease test [RUT]) and non‐invasive (stool antigen [FemtoLab H. pylori], urea breath test [UBT]) tests in the diagnosis of H. pylori infection and post‐treatment eradication in children and adolescents.Methods:Ninety‐two patients (50 male, 42 female) referred for upper gastrointestinal endoscopy were prospectively enrolled. UBT was performed and stool specimens collected for monoclonal enzyme immunoassay for H. pylori antigen (FemtoLab) 1 to 4 days before endoscopy. H. pylori in gastric biopsies was evaluated by RUT and staining with hematoxylin‐eosin and giemsa. Eradication therapy was given to children with abdominal pain and H. pylori gastritis. FemtoLab H. pylori and UBT were repeated 6 weeks after the end of triple therapy.Results:Histology identified H. pylori in 49 of 92 (53%) subjects. Concordance between histology and RUT was found in 78 of 92 children. FemtoLab H. pylori was positive in 41 of 78 (52.6%) children with sensitivity, specificity, positive and negative predictive values of 97.5%, 94.7%, 95.1% and 97.3%, respectively. For UBT, these values were 100%, 96.9%, 97.5% and 100%, respectively. Twenty‐six of 36 patients who received triple therapy returned for eradication evaluation. Tests for H. pylori antigen in stool were positive in 10 of 26 and for UBT in 11 of 26.Conclusion:Stool antigen (FemtoLab) and UBT were equally effective in diagnosing and confirming eradication of H. pylori infection in children.

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Section: Methodsmentioning

confidence: 99%

Comparison of Invasive and Non‐Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children

Hino,

Eliakim,

Levine

et al. 2004

J. pediatr. gastroenterol. nutr.

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Non-invasive diagnostic tests for Helicobacter pylori infection

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Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

142

130

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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Substitute, inexpensive diagnosis of H. pylori infection by infra-red(IR) spectrophotometer in 13C-urea breath test

Cited by 2 publications

References 0 publications

Comparison of Invasive and Non‐Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children

Comparison of Invasive and Non‐Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children

Non-invasive diagnostic tests for Helicobacter pylori infection

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