Abstract:Nucleotide-fueled conformational changes in motor proteins are key to many important cell functions. Inspired by this biological behavior, we report a simple chemical system that exhibits carbodiimide-fueled geometry changes. Bridging via transient anhydride formation leads to a significant reduction of the twist about the biaryl bond of substituted diphenic acids, giving a simple molecular clamp. The kinetics are well-described by a simple mechanism, allowing structure–property effects to be determined. The k… Show more
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