This paper addresses in-situ stress-estimation methods based on the Kaiser effect. The physical and mechanical properties of granite, diorite, and granodiorite samples selected at different depth intervals of the core obtained from a wellbore were examined. The ultimate uniaxial compressive strength, modulus of elasticity, and Poisson’s ratio of the rock samples were determined using presses and strain gauges. Also, local longitudinal and shear wave velocities were measured using a high-accuracy laser-ultrasonic system with a view to assessing the structure of the samples. Based on the resulting elastic wave velocity maps, samples with no obvious discontinuities were chosen. These undisturbed samples were subjected to uniaxial compression and their acoustic emission was simultaneously measured. In-situ stresses were estimated from the results of the interpretation of acoustic emission measurements. The experimental in-situ stresses were compared with the results of a numerical simulation. The ratio of the estimated in-situ stresses to the calculated ones is within the range from 0.81 to 1.11. This means that the laser ultrasonic and acoustic emission methods make it possible to effectively estimate in-situ stresses in a rock mass and assess the degree of rock mass damage.