Substantial alterations of the intestinal microbiota in psoriasis patients of China

Abstract

Substantial alterations of the intestinal microbiota in psoriasis patients of ChinaPsoriasis is an immune-mediated inflammatory skin condition.Accumulating evidence suggests that there is an intimate relationship between intestinal dysbiosis and psoriasis. In order to evaluate

Characterization of Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review

“…All studies examined adults, except one study examining both children and adults (age range 10–82 years) ( 11 ) and, in most studies, the psoriatic population was age- and sex-matched with the control population ( 12 – 23 ). Nine studies included patients with plaque psoriasis only ( 11 – 13 , 18 , 20 , 23 – 26 ), 6 studies included patients with mixed psoriasis types ( 15 , 17 , 21 , 22 , 27 , 28 ) and 7 studies did not specify the type of psoriasis ( 14 , 16 , 19 , 29 – 32 ). Fifteen studies examined patients with mild, moderate or severe psoriasis ( 11 – 13 , 15 – 22 , 24 , 25 , 27 , 29 ), 2 studies examined patients with mild psoriasis ( 14 , 32 ) and 4 studies reported no information on psoriasis severity ( 23 , 28 , 30 , 31 ).…”

“…Nine studies included patients with plaque psoriasis only ( 11 – 13 , 18 , 20 , 23 – 26 ), 6 studies included patients with mixed psoriasis types ( 15 , 17 , 21 , 22 , 27 , 28 ) and 7 studies did not specify the type of psoriasis ( 14 , 16 , 19 , 29 – 32 ). Fifteen studies examined patients with mild, moderate or severe psoriasis ( 11 – 13 , 15 – 22 , 24 , 25 , 27 , 29 ), 2 studies examined patients with mild psoriasis ( 14 , 32 ) and 4 studies reported no information on psoriasis severity ( 23 , 28 , 30 , 31 ).…”

“…The studies included 4,379 participants, of whom 1,388 had psoriasis and 36 had PsA. All studies examined adults, except one study examining both children and adults (age range 10-82 years) (11) and, in most studies, the psoriatic population was age-and sex-matched with the control population (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Nine studies included patients with plaque psoriasis only (11-13, 18, 20, 23-26), 6 studies included patients with mixed psoriasis types (15,17,21,22,27,28) and 7 studies did not specify the type of psoriasis (14,16,19,(29)(30)(31)(32).…”

Recent progress at the psoriasis and atopic dermatitis research front: An experimental dermatology perspective

“…Increasing evidence suggests that intestinal dysbiosis is closely associated with PSO 34,35 . In a recent study, 36 stool samples were collected from 20 psoriatic patients and 20 healthy controls, and bacterial 16S sequencing was performed to determine how gut microbiota is differed between the two groups. At the genus level, psoriatic group showed a higher abundance of Megamonas and lower abundance of Romboutsia species compared with healthy controls.…”

In search of the needle in a haystack: Finding a suitable serum biomarker for monitoring disease activity of systemic sclerosis

“…In contrast to psoriasis, 1‐25 atopic dermatitis 26‐47 and pruritus 21,35,48‐70 whose therapeutic landscapes have dramatically changed over the last few years due to many advances in skin research, scleroderma remains a challenge in many aspects.…”