Substance use, microbiome and psychiatric disorders

Chivero, Ernest T.; Sil, Susmita; Kumar, Mohit; Buch, Shilpa

doi:10.1016/j.pbb.2022.173432

Cited by 8 publications

(5 citation statements)

References 210 publications

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“…That SUD has a reciprocal relation with GBA and is associated with dysbiosis [91][92][93]. GBA communication is manifested through different mechanisms including the immune response, where the bacterial products may alter the intestinal barrier allowing such products to enter the bloodstream and induce inflammatory response.…”

Section: Gut Microbiota and Drug Addictionmentioning

confidence: 99%

“…Among substances of abuse, alcohol causes dysbiosis and peripheral inflammation, and its withdrawal has been shown to cause neuroinflammation [91]. Similarly, chronic morphine or cocaine result in dysbiosis, increased intestinal permeability and neuroinflammation, which can in turn influence the drug response [91] [92].…”

Section: Gut Microbiota and Drug Addictionmentioning

confidence: 99%

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Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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Section: Gut Microbiota and Drug Addictionmentioning

confidence: 99%

Section: Gut Microbiota and Drug Addictionmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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“…Cocaine abusers also exhibit epigenetic modifications of genes involved in neuroplasticity and innate immunity [ 28 , 29 ]. Preliminary data also suggest that recreational drugs can modify the microbiome, thereby facilitating the onset of several psychiatric conditions, including psychotic disorders [ 30 ]. Despite these findings, the current literature does not provide a clear identification of peripheral biological parameters that can indicate the prognosis of SIPD patients based on the type of abused substance.…”

Section: Introductionmentioning

confidence: 99%

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse

Di Paolo,

Calabrese,

Nosari

et al. 2024

JPM

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Background: The present retrospective observational study aims to identify differences in clinical features and peripheral biomarkers among patients affected by substance-induced psychotic disorder (SIPD) according to the primary substance of abuse. Methods: A sample of 218 patients was divided into three groups according to the type of consumed substance: alcohol, cannabis, and psychostimulants. The three groups were compared using one-way analyses of variance (ANOVAs) for continuous variables and χ2 tests for qualitative variables. After excluding the alcohol-induced psychotic disorder group, the same analyses were repeated. The statistically significant variables from these subsequent analyses were included in a binary logistic regression model to confirm their reliability as predictors of cannabis- or psychostimulant-induced psychotic disorder. Results: Psychotic cannabis abusers were younger (p < 0.01), with illness onset at an earlier age (p < 0.01). Alcohol consumers presented a longer duration of illness (p < 0.01), more frequent previous hospitalizations (p = 0.04) and medical comorbidities (p < 0.01), and higher mean Modified Sad Persons Scale scores (p < 0.01). Finally, psychostimulant abusers had a higher frequency of lifetime history of poly-substance use disorders (p < 0.01). A binary logistic regression analysis revealed that higher mean Brief Psychiatric Rating Scale scores (p < 0.01) and higher sodium (p = 0.012) and hemoglobin (p = 0.040) plasma levels were predictors of cannabis misuse in SIPD patients. Conclusions: Different clinical factors and biochemical parameters con be associated with SIPD according to the main substance of abuse, thus requiring specific management by clinicians.

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“…The role of the microbiome in SUD is gaining increasing recognition (reviewed in 10,11 ). Previous studies in mice have shown that antibiotic ablation of the microbiome alters low‐dose cocaine sensitization and conditioned place preference (CPP) in male C57BL/6J mice 12 .…”

Section: Introductionmentioning

confidence: 99%

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

Tran,

Monroy Hernandez,

Nguyen

et al. 2023

Genes Brain and Behavior

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The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug selfadministration behavior in mice. Here, we profile the composition of the naïve micro-

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Substance use, microbiome and psychiatric disorders

Cited by 8 publications

References 210 publications

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Depression and Drug Addiction

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Differences Related to Alcohol, Cannabis, and Psychostimulant Abuse

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

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