Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications

Wei, Yufeng; Shah, Rameen

doi:10.3390/ph13070155

Cited by 106 publications

(108 citation statements)

References 246 publications

(380 reference statements)

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“…Pre-existing comorbidities in tobacco users such as cardiovascular diseases, diabetes, respiratory diseases, and hypertension are found to further aggravate the disease manifestations [58][59][60]. Being an important immune modulator, tobacco significantly suppresses the immune system by reducing antibody responses and T-cell proliferation, thereby increasing the susceptibility of tobacco users towards acute viral infections [61]. A population vulnerability analysis done in Europe indicated that elderly people and those with low immunity are at higher risk of developing severe health consequences from COVID-19 [62].…”

Section: Tobacco Use In the Vulnerable Population Including Adolescentsmentioning

confidence: 99%

Tobacco use as a well-recognized cause of severe COVID-19 manifestations

Gupta

Nethan

Mehrotra

2021

Respiratory Medicine

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Introduction: The Coronavirus disease (COVID-19) infection is caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) primarily affecting the lungs. All tobacco-related illnesses including asthma, chronic obstructive pulmonary disease (COPD), and coronary artery disease are known to reduce the lung capacity and impair the immune system of the body and can greatly influence the ability to fight the novel coronavirus. The purpose of this state-of-the-art literature review is to summarize the evidence of the association of tobacco use with the severity of the COVID-19 manifestations. Method: Articles describing the association of tobacco use with the severity of COVID-19 manifestations were searched on PubMed, MEDLINE, and Google. This review covers the relevant studies on the subject published from January 1, 2020 to September 10, 2020. Results: Tobacco use in all forms, whether smoking or chewing, is significantly associated with severe COVID-19 outcomes. Pre-existing comorbidities in tobacco users such as cardiovascular diseases, diabetes, respiratory diseases and hypertension were found to further aggravate the disease manifestations making the treatment of such COVID-19 patients more challenging due to their rapid clinical deterioration. Conclusions: Current review indicates that nicotine exposure is linked to cardiopulmonary vulnerability to COVID-19 and tobacco use can be a potential risk factor for not only getting the viral infection but also its severe manifestations. The current pandemic provides a teachable moment to break the cycle of nicotine addiction and accelerate national tobacco control programs to achieve a tobacco-free world.

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Section: Tobacco Use In the Vulnerable Population Including Adolescentsmentioning

confidence: 99%

Tobacco use as a well-recognized cause of severe COVID-19 manifestations

Gupta

Nethan

Mehrotra

2021

Respiratory Medicine

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“…Substance abuse was a risk factor for COVID-19 severity in the current study, which can be the result of direct damage to the respiratory system, modulating brain and immune functions (19). Severe disease was also associated with travel to high-risk areas.…”

Section: Discussionmentioning

confidence: 52%

Epidemiological and Clinical Risk Factors Related to Severe COVID-19 in Iran: A multi-center study

Hashemi-Shahri¹,

Tabatabaei²,

Ansari‐Moghaddam³

et al. 2020

Preprint

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Background Iran was one of the first countries to be affected by COVID-19. Identifying factors associated with severity of COVID-19 is effective in disease management. This study investigated the epidemiological and clinical features and factors associated with severity of COVID-19 in one of the less privileged areas in Iran.Methods In a multi-center study, all patients admitted to hospitals of Zahedan University of Medical Sciences located in southeastern Iran were investigated from February 29 to April 31, 2020. Demographic, epidemiological and clinical data of patients were extracted from medical records. To explore the risk factors associated with severity of COVID-19, bivariate and multivariate logistic regression models were used.Results Among the 413 patients, 55.5% were male and 145 (35.10%) were in a severe condition at admission time. Multivariate analysis showed that the adjusted odds of the disease severity increased in patients with older age (OR 3.51; 95% CI, 2.28-5.40), substance abuse (OR 2.22; 95% CI, 2.05-5.78) and at least one underlying disease (OR 3.45; 95% CI, 1.01-1.32).Conclusions COVID-19 was more severe in older patients, patients with a history of substance abuse, and patients with at least one underlying disease. Understanding the factors affecting the disease severity can help for clinical management of COVID-19, especially in less privileged areas where fewer resources are available.

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“…Substance abuse was a risk factor for COVID-19 severity in the current study, resulting from direct damage to the respiratory system, modulating brain, and immune functions (19). Severe disease was also associated with travel to high-risk areas.…”

Section: Discussionmentioning

confidence: 55%

Epidemiological and Clinical Risk Factors Related to Severe COVID-19 in Iran: A multi-center study

Hashemi-Shahri

Tabatabaei

Ansari‐Moghaddam

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Iran was one of the first countries to be affected by COVID-19. Identifying factors associated with the severity of COVID-19 is useful in disease management. This study investigated the epidemiological and clinical features and factors related to severe COVID-19 in Iran's less-privileged area.MethodsIn a multicenter study, all patients admitted to Zahedan University of Medical Sciences hospitals located in southeastern Iran were investigated from February 29 to April 31, 2020. The demographic, epidemiological, and clinical data of patients were extracted from medical records. To explore the risk factors associated with the severity of COVID-19, bivariate and multivariate logistic regression models were used. ResultsAmong the 413 patients, 55.5% were male, and 145 (35.10%) were in severe condition at admission time. Multivariate analysis showed that the adjusted odds of the disease severity increased in patients with older age (OR 3.51; 95% CI, 2.28-5.40), substance abuse (OR 2.22; 95% CI, 2.05-5.78), and at least one underlying disease (OR 3.45; 95% CI, 1.01-1.32).Conclusions COVID-19 was more severe in older patients, patients with a history of substance abuse, and patients with at least one underlying disease. Understanding the factors affecting the disease severity can help for the clinical management of COVID-19, especially in less privileged areas where fewer resources are available.

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Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications

Cited by 106 publications

References 246 publications

Tobacco use as a well-recognized cause of severe COVID-19 manifestations

Tobacco use as a well-recognized cause of severe COVID-19 manifestations

Epidemiological and Clinical Risk Factors Related to Severe COVID-19 in Iran: A multi-center study

Epidemiological and Clinical Risk Factors Related to Severe COVID-19 in Iran: A multi-center study

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