Substance Use Among Young Adult Survivors of Childhood Cancer With Cognitive Impairment: An Analysis of the Project Forward Cohort

Ng, Ding Quan; Ritt-Olson, Anamara; Freyer, David R.; Miller, Kimberly A.; Schlüter, Thomas; Milam, Joel; Chan, Alexandre

doi:10.1200/op.22.00458

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…studied substance misuse among young adult childhood cancer survivors (median age: 26.5y). They found that, among these survivors, substance misuse behavior proportion was 34% for binge drinking, 11% for cigarette use, and 7% for e-cigarette/vaporizer use [ 12 ]. Cappelli et al .…”

Section: Introductionmentioning

confidence: 99%

Health-related risk behaviors among U.S. childhood cancer survivors: a nationwide estimate

Nghiem,

Jin,

Mennemeyer

et al. 2024

BMC Cancer

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Background Childhood cancer survivors (CCS) are subject to a substantial burden of treatment-related morbidity. Engaging in health protective behaviors and eliminating risk behaviors are critical to preventing chronic diseases and premature deaths. This study is aimed to provide updated information on currently smoking, physical inactivity, binge drinking patterns and associated factors among CCS using a nationwide dataset. Methods We constructed a sample of CCS (cancer diagnosis at ages < 21y) and healthy controls (matched on age, sex, residency, race/ethnicity) using 2020 Behavioral Risk Factor Surveillance System. We used Chi-square tests and Wilcoxon rank-sum test to examine differences in sociodemographics and clinical characteristics between two groups. Logistic, ordinal regression and multivariable models (conditional models for matching) were used to determine factors associated with risk behaviors. Results The final sample (18-80y) included 372 CCS and 1107 controls. Compared to controls, CCS had a similar proportion of binge drinking (~ 18%) but higher prevalence of currently smoking (26.6% vs. 14.4%, p < 0.001), physical inactivity (23.7% vs. 17.7%, p = 0.012), and of having 2-or-3 risk behaviors (17.2% vs. 8.1%, p < 0.001). Younger age, lower educational attainment, and having multiple chronic health conditions were associated with engaging in more risk behaviors among CCS. Females, compared to male counterparts, had lower odds of binge drinking (adjusted odds ratio (aOR) = 0.30, 95% confidence interval (CI): 0.16–0.57) among CCS but not in all sample. Having multiple chronic health conditions increased odds of both currently smoking (aOR = 3.52 95%CI: 1.76–7.02) and binge drinking (aOR = 2.13 95%CI: 1.11–4.08) among CCS while it only increased odds of currently smoking in all sample. Discussion Our study provided risk behavior information for wide age-range CCS, which is currently lacking. Every one in four CCS was currently smoking. Interventions targeting risk behavior reduction should focus on CCS with multiple chronic health conditions.

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Section: Introductionmentioning

confidence: 99%

Health-related risk behaviors among U.S. childhood cancer survivors: a nationwide estimate

Nghiem,

Jin,

Mennemeyer

et al. 2024

BMC Cancer

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Clinical, demographic factors, and substance use among Hispanic and non-Hispanic young adult childhood cancer survivors

Kim,

Huh,

Miller

et al. 2024

Journal of Psychosocial Oncology

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Purpose. The purpose of this study is to examine the protective and risk factors of substance use behaviors (tobacco, marijuana, e-cigarette, and alcohol) among young adult childhood cancer survivors. The study focused on clinical care and status (receipt of cancer-related follow-up care, treatment intensity, late effects, depressive symptoms, self-rated health) and demographic (race/ethnicity, neighborhood socioeconomic status) factors and their associations with polysubstance use. Methods. Participants were from the Project Forward cohort, a population-based study of young adult survivors of childhood cancers. Participants (N=1,166, M age =25.1 years) were recruited through the Los Angeles Cancer Surveillance Program (Cancer Registry covering Los Angeles County, California). Multivariate path analyses were performed with substance use as the outcome variables and clinical and demographic factors as independent variables. Covariates included age and sex. Finding. Substance use was positively associated with depressive symptoms, and inversely associated with cancer-related follow-up care, female sex, age, Hispanic ethnicity, treatment intensity, and self-rated health. Neighborhood SES was inversely associated with tobacco use, while being positively associated with binge drinking and e-cigarette use. The results highlight the interrelationship between the clinical and demographic variables and their associations with different substance use. 2 SUBSTANCE USE IN YOUNG ADULT CCS Conclusion. Findings support the need for effective interventions targeting polysubstance use behavior among CCS. This will help improve long-term outcomes and mitigate the risk for early morbidity.

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Substance Use Among Young Adult Survivors of Childhood Cancer With Cognitive Impairment: An Analysis of the Project Forward Cohort

Cited by 2 publications

References 46 publications

Health-related risk behaviors among U.S. childhood cancer survivors: a nationwide estimate

Health-related risk behaviors among U.S. childhood cancer survivors: a nationwide estimate

Clinical, demographic factors, and substance use among Hispanic and non-Hispanic young adult childhood cancer survivors

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