Substance use among university students and affecting factors in Marrakech region, Morocco: a cross-sectional Study

BASLAM, ABDELMOUNAIM; KABDY, HAMID; Moubtakir, Soad; ABOUFATIMA, RACHIDA; Boussaa, Samia; Chait, Abderrahman

doi:10.21203/rs.3.rs-1961768/v1

Cited by 2 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The utilization of herbal remedies for treatment can be traced back to ancient times (Newman and Cragg., 2020) . Recently, there has been a resurgence of interest in medicinal plants, driven by the compelling results achieved by scientists in the field of phytotherapy (Baslam et al, 2023). Medicinal plants find widespread use globally in combating various diseases and their associated symptoms (Howes et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

ANALGESIC AND ANTI-LITHIASIC EFFECTS OF MOROCCAN Citrus aurantium FLOWERS AND FRUIT AQUEOUS EXTRACTS

2024

THE JAPS

View full text Add to dashboard Cite

Citrus aurantium holds widespread use in Moroccan society as a remedy for various diseases, owing to its significant pharmacological properties. The objective of this study was to investigate the antioxidant activity, analgesic potential, and anti-lithiasis properties of the aqueous extracts of both the fruits and juice of Citrus aurantium. To achieve this, we employed various techniques: antioxidant activity was assessed using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and reducing power assays (FRAP), while the antinociceptive effect of the plant was evaluated through writhing and hotplate tests on mice. The urolithiasis model was induced in rats through the administration of ethylene glycol and ammonium chloride, and assessments were made based on variations in body weight, kidney histopathology, and biochemical analysis using urea and creatinine. Our findings demonstrated significant antioxidant activity in both extracts (flowers and juice) of Citrus aurantium, represented by DPPH values of 5.42±0.20 and 2.87±0.42, and FRAP values of 4.23±0.05 and 1.67±0.13 in flowers and juice, respectively. The obtained results also showed that Citrus aurantium extracts significantly reduced the number of writhes and increased the latency time in response to a thermal stimulus compared to the control group (p≤0.001). Both extracts (flowers and juice) of Citrus aurantium exhibited a protective effect on the kidneys by preventing the formation of oxalo-calcium crystals. The histopathological study of the kidneys in the groups treated with Citrus aurantium revealed a marked reduction in abnormalities observed in rats treated with Ethylene Glycol. Additionally, urea and creatinine values were reduced compared to the control group (p≤0.001), signifying an important anti-urolithiasic activity. Overall, Citrus aurantium demonstrated potent antioxidant, analgesic and antilithic activities, suggesting its potential as a valuable natural source of bioactive compounds with various therapeutic applications.

show abstract

Section: Introductionmentioning

confidence: 99%

ANALGESIC AND ANTI-LITHIASIC EFFECTS OF MOROCCAN Citrus aurantium FLOWERS AND FRUIT AQUEOUS EXTRACTS

2024

THE JAPS

View full text Add to dashboard Cite

show abstract

“…The pervasive impact of SUD is evident in its contribution to high disability rates, premature deaths, and substantial economic burdens on the healthcare, law enforcement, and productivity sectors [ 2 ]. With approximately 300 million individuals worldwide using psychoactive substances and 39.5 million suffering from SUD, the need for effective treatment interventions is paramount [United Nations Office on Drugs and Crime, UNODC] [ 3 ]. Opioids, particularly Fentanyl, have emerged as a major concern, impacting a significant portion of the global population (3.8%) and posing serious public health risks [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum

Baslam,

Kabdy,

Chait

et al. 2024

Biomedicines

Self Cite

View full text Add to dashboard Cite

The escalating rates of morbidity and mortality associated with opioid use disorder (OUD) have spurred a critical need for improved treatment outcomes. This study aimed to investigate the impact of prolonged exposure to Fentanyl, a potent opioid, on behavior, biochemical markers, oxidative stress, and the composition of the gut microbiome. Additionally, we sought to explore the therapeutic potential of Anacyclus pyrethrum in mitigating the adverse effects of Fentanyl withdrawal. The study unveiled that chronic Fentanyl administration induced a withdrawal syndrome characterized by elevated cortisol levels (12.09 mg/mL, compared to 6.3 mg/mL for the control group). This was accompanied by heightened anxiety, indicated by a reduction in time spent and entries made into the open arm in the Elevated Plus Maze Test, as well as depressive-like behaviors, manifested through increased immobility time in the Forced Swim Test. Additionally, Fentanyl exposure correlated with decreased gut microbiome density and diversity, coupled with heightened oxidative stress levels, evidenced by elevated malondialdehyde (MDA) and reduced levels of catalase (CAT) and superoxide dismutase (SOD). However, both post- and co-administration of A. pyrethrum exhibited substantial improvements in these adverse effects, effectively alleviating symptoms associated with OUD withdrawal syndrome and eliciting positive influences on gut microbiota. In conclusion, this research underscores the therapeutic potential of A. pyrethrum in managing Fentanyl withdrawal symptoms. The findings indicate promising effects in alleviating behavioral impairments, reducing stress, restoring gut microbiota, and mitigating oxidative stress, offering valuable insights for addressing the challenges of OUD treatment.

show abstract

Substance use among university students and affecting factors in Marrakech region, Morocco: a cross-sectional Study

Cited by 2 publications

References 28 publications

ANALGESIC AND ANTI-LITHIASIC EFFECTS OF MOROCCAN Citrus aurantium FLOWERS AND FRUIT AQUEOUS EXTRACTS

ANALGESIC AND ANTI-LITHIASIC EFFECTS OF MOROCCAN Citrus aurantium FLOWERS AND FRUIT AQUEOUS EXTRACTS

Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum

Contact Info

Product

Resources

About