Substance P release from spinal cord slices by capsaicin

Mechanism of action of nicotine in isolated iris sphincter preparations of rabbit

“…The response to a nearly maximum concentration of nicotine (0.1 mM) was 1.56 + 0.08 mN and 58.7 + 1.8% of the maximum response to carbachol (30upM: 2.75 + 0.14 mN, n = 83) (Figure 2). ed applications of capsaicin (1OkIM), which releases and depletes tachykinins from trigeminal nerve endings (Gamse et al, 1979;Theriault et al, 1979) arations with atropine or simultaneous treatment -log M with rpwwL-SP and atropine almost abolished the Table 1, the contractile response to nicotine-induced contraction (Table 1). 0.1 mm nicotine was blocked by hexamethonium During chronic nicotine treatment, each rabbit (Figure la).…”

“…It is well known that capsaicin releases tachykinins from chemosensitive C-fibre afferents (Gamse et al, 1979;Theriault et al, 1979) of the ophthalmic trigeminal nerve in the eye (Ueda et al, 1982). It has been recently reported that there are mRNAs of preprotachykinins A, precursors of substance P (SP) and neurokinin A (NKA) in the trigeminal ganglion (Nawa et al, 1984), and that SP, NKA and neurokinin B (NKB), three mammalian tachykinins, are all present in rabbit iris sphincter (Taniguchi et al, 1986).…”

Capsaicin and nicotine‐sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis

“…Increasing evidence from experimental tion of irritants (Lundblad et al, 1985). The studies suggests that unmyelinated, capsaicincapsaicin-sensitive nerves in the nose have been sensitive sensory C-fibres play an important role in a shown to contain tachykinins such as substance P (SP) (Hokfelt et al, 1977;Lundblad et al, 1983; dense network under and within the lining epithelium of the nasal mucosa as well as around blood vessels (Lundblad et al, 1983, Uddman et al, 1985 Capsaicin, the pungent agent in hot pepper and paprica, which selectively activates chemosensitive C-fibre afferents, induces a local and central release of SP, CGRP and other neuropeptides from these neurones (Gamse et al, 1979;Saria et al, 1986;Hua et al, 1986). In a preliminary study, we demonstrated that local application of capsaicin to the human nasal mucosa induces sneezing and secretion (Lundblad et al, 1987a,b).…”

Effects of capsaicin desensitization on the stimulatory effect of kinins, prostaglandins, biogenic amines and various drugs in guinea‐pig isolated atria

“…Evidence has 1 Author for correspondence. accumulated in recent years to indicate that the acute effect of capsaicin is to stimulate primary sensory neurones and trigger the release of several neuropeptides, primarily substance P (SP) and calcitonin gene-related peptide (CGRP), from peripheral and central branches of primary sensory neurones (Gamse et al, 1979;Skofitsch et al, 1985;Hua et al, 1985;Saria et al, 1986). Other studies have shown that chronic treatment of animals with capsaicin produces extensive depletion of primary afferents of their SP and CGRP content (Papka et al, 1981;Gibbins et al, 1985;Lundberg et al, 1985;Saito et al, 1986).…”