Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection
Michael Cremin,
Valerie T. Ramirez,
Kristina Sanchez
et al.
Abstract:Immune responses in the intestine are intricately balanced to prevent pathogen entry without inducing immunopathology. The nervous system is well-established to interface with the immune system to fine-tune immunity in various organ systems including the gastrointestinal tract. Specialized sensory neurons can detect bacteria, bacterial products, and the resulting inflammation, to coordinate the immune response in the gastrointestinal tract. These sensory neurons release peptide neurotransmitters such as Substa… Show more
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