Substance P: multifunctional peptide in the hypothalamo-pituitary system?

Jessop, DS; Chowdrey, Hardial S.; Larsen, Philip J.; Lightman, Stafford L.

doi:10.1677/joe.0.1320331

Cited by 84 publications

(37 citation statements)

References 59 publications

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“…SP, a member of the neurokinin peptide family, is found in the ME and PVN in significant amounts and has been implicated in a wide variety of neuroendocrine functions ( Jessop et al 1992). Intracerebroventricular injection of SP in rats resulted in decreased circulating ACTH (Chowdrey et al 1990) while SP inhibited the release of CRH from rat hypothalami in vitro, but not from isolated ME tissue , indicating a role within the PVN.…”

Section: Substance P (Sp)mentioning

confidence: 99%

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis

Jessop

1999

Journal of Endocrinology

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Section: Substance P (Sp)mentioning

confidence: 99%

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis

Jessop

1999

Journal of Endocrinology

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“…Furthermore, post-surgical stress (removal of the pituitary tumour) as well as growth factor synthesis by the tumourous tissue in vitro modulate hormone secretion (26)(27)(28). It is possible that TBP (bioactive fraction of the human plasma ultrafiltrate) contains factor(s) involved in the stress reaction or paracrine regulation of the growth factor synthesis, thus indirectly affecting the hormone release, but these possibilities have to be further evaluated.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the In Vitro Secretory Activity of Human Pituitary Adenomas: Modification of Corticotropin Release from Adenoma Tissue Explant Cultures by Addition of a Human Plasma Ultrafiltrate Bioactive Fraction

Žarković¹,

Hayn²,

Plavšić³

et al. 1996

CCLM

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Summary: The lack of control of tumour behaviour is manifested in different ways, depending primarily on the type of tumour. This results in numerous problems of tumour diagnosis and therapy. In the case of "benign" tumours, like pituitary adenomas, in vitro studies are often used for evaluation of the tumour. The use of tissue explant cultures of human pituitary adenomas and the comparison of the feature of cultured tumours with their behaviour in vivo showed that corticotropin is released not only from the tumours associated with Gushing^ disease, but also from clinically non-functioning tumours. Hence, it was supposed that the release of corticotropin in vivo from non-secreting tumours is probably under the influence of certain neuroendocrine and/or systemic humoral factors. To test this possibility, samples of 22 tumours were cultured in plain culture medium or in the presence of the "human plasma ultrafiltrate bioactive fraction" (tentatively termed as TBP) prepared by anion-exchange chromatography. In the presence of TBP the release of corticotropin was strongly inhibited in adenomas showing relatively high spontaneous secreting activity in vitro (> 200 ng/1 in 24 hours), while immunohistochemistry of these tumours indicated accumulation of corticotropin inside the cells. In contrast, TBP stimulated corticotropin release from tumours that showed relatively low basic corticotropin release (< 200 ng/1 in 24 hours), with no obvious change in cellular corticotropin immunoreactivity. Such a dual activity of TBP was not observed for 8 samples of adenomas cultured in the presence of surrounding pituitary tissue, probably because TBP did not affect corticotropin secretion by the normal pituitary cells (as indicated by immunohistochemistry). From these results, it appears that TBP could be one of the humoral factors involved in the regulation of corticotropin release from pituitary adenoma tissue. Its possible involvement in the regulation of corticotropin release from normal pituitary tissue, however, is uncertain.

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“…Interestingly, in chronic inflammatory states, in which chronic central elevations of substance P may take place, an impairment of HPA axis responsiveness to stimuli or stress is observed, probably because of the suppressive effect of substance P on the CRH neuron. [27][28][29] Such an impairment has been observed in African trypanosomiasis, the acquired immunodeficiency syndrome, and extensive burns in humans and in chronic animal models of inflammation. [29,103,[114][115][116][117] Inflammatory mediators other than the three inflammatory cytokines may also participate in activation of the HPA axis.…”

Section: Stress System: Immune System Interactions Effects Of the Immmentioning

confidence: 95%

“…[27][28][29] Such an impairment has been observed in African trypanosomiasis, the acquired immunodeficiency syndrome, and extensive burns in humans and in chronic animal models of inflammation. [29,103,[114][115][116][117] Inflammatory mediators other than the three inflammatory cytokines may also participate in activation of the HPA axis. Thus, several eicosanoids, platelet-activating factor, and epidermal growth factor have strong CRH-releasing abilities.…”

Section: Stress System: Immune System Interactions Effects Of the Immmentioning

confidence: 95%

“…[26] Substance P has actions reciprocal to those of NPY, because it inhibits the PVN CRH neuron [27] but activates the LC/NE-sympathetic system. [28] Presumably, the level of substance P is elevated centrally, when there is peripheral activation of somatic afferent fibers, [29] and thus may have relevance to changes in stress system activity in chronic inflammatory or painful states.…”

Section: Homeostasis: Stress Syndrome Phenomenologymentioning

confidence: 99%

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Organization and Integration of the Endocrine System: The Arousal and Sleep Perspective

Chrousos

2007

Sleep Medicine Clinics

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Substance P: multifunctional peptide in the hypothalamo-pituitary system?

Cited by 84 publications

References 59 publications

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis

Analysis of the In Vitro Secretory Activity of Human Pituitary Adenomas: Modification of Corticotropin Release from Adenoma Tissue Explant Cultures by Addition of a Human Plasma Ultrafiltrate Bioactive Fraction

Organization and Integration of the Endocrine System: The Arousal and Sleep Perspective

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