Substance P modulating effect on the binding capacity of hamster Leydig cell LH receptors

Kanchev, L.N.; Konakchieva, Rossitza; Angelova, P.; Davidoff, M

doi:10.1016/0024-3205(95)00130-x

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…1). These disparate results obtained by Kanchev et al (1995) in Leydig cells from hamsters under short vs. long photoperiods, although potentially important, are, however, difficult to explain. Using an incubation of freshly dispersed testicular cells from adult mouse testes obtained by mechanical dissociation, we confirmed that SP and NKA decreased both the basal and the hCG-induced release of testosterone.…”

Section: Effects Of Tachykinins On the Testesmentioning

confidence: 82%

“…Using an incubation of freshly dispersed testicular cells from adult mouse testes obtained by mechanical dissociation, we confirmed that SP and NKA decreased both the basal and the hCG-induced release of testosterone. Kanchev et al (1995) reported that SP was able to reduce the number of LH receptors in Leydig cells obtained from testes of hamsters that had been kept under short daily photoperiods. But SP induced an increase of LH receptors when Leydig cells from testes of hamsters kept under long photoperiods were used.…”

Section: Leydig Cellsmentioning

confidence: 99%

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Tachykinins and their possible modulatory role on testicular function: a review

2003

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Tachykinins are vasoactive and smooth muscle-contracting peptides with widespread localizations. Tachykinins have been localized in the nerve fibres that supply the testes, in the Leydig cells of different animal species, and also in Sertoli cells of the Siberian hamster testes. The presence of substance P (SP) has also been demonstrated in ejaculated human spermatozoa and in the seminal plasma. Tachykinins have been shown to inhibit the release of testosterone by testicular fragments or by isolated Leydig cells in vitro. Acting on Sertoli cells, tachykinins have been shown to stimulate the release of lactate and transferrin by these cells in vitro, and also to stimulate aromatase activity. Leydig and Sertoli cells express the Preprotachykinin A gene, and this fact strongly suggests that tachykinins can be synthesized in the testes. These findings suggest that tachykinins may have a physiological function in the testes as modulators of the functions of the different cell types contained in these organs.

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Section: Effects Of Tachykinins On the Testesmentioning

confidence: 82%

Section: Leydig Cellsmentioning

confidence: 99%

Tachykinins and their possible modulatory role on testicular function: a review

2003

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“…Pituitary adenylate cyclase-activating peptide (PACAP), for instance, stimulates testosterone secretion from Leydig cells through activation of pertussis toxin-sensitive G protein coupled to its receptors (Rossato et al 1997), whereas substance P (SP) reduces the number of luteinizing hormone-binding sites in Leydig cells and inhibits their testosterone production (Kanchev et al 1995). NPY could also have a role in testicular steroidogenesis, as has been suggested in the ovary (Barreca et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Peptidergic not monoaminergic fibers profusely innervate the young adult human testis

Gong

Feng

et al. 2009

Journal of Anatomy

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Numerous studies have reported that intratesticular nerves exert important regulatory effects on the functions of the male gonad; however, as yet little is known about their distribution in the young adult human testis. The purpose of this study was to explore whether peptidergic and adrenergic nerves occur in the male gonad of this age, and, if present, to depict their distribution further. Thirty testes were collected from 15 reproductively healthy donors aged 21-32 years. Antibodies against protein gene product 9.5 (PGP 9.5), neuropeptide Y (NPY), C-terminal flanking peptide of NPY (CPON) and vasoactive intestinal peptide (VIP) were employed for immunohistochemical detection of intratesticular peptidergic nerves, and those against dopamine-beta-hydroxylase (DBH) and 5-hydroxytryptamine (5-HT) for monoaminergic ones. The testicular parenchyma exhibited a rich innervation by PGP 9.5-positive fibers, mainly associated with Leydig cell nests, blood vessels, and seminiferous tubules. Numerous NPY-and CPON-immunoreactive (IR) nerves also appeared in the gonads, but the vast majority were confined to blood vessels. A small number of VIP-IR fibers were detected in some arterioles. By contrast, however, no fibers displaying DBH or 5-HT immunoreactivity were observed within the testis. Additionally, expression of PGP-9.5, NPY, CPON, VIP, DBH and 5-HT was found in Leydig cells, PGP 9.5 in spermatogonia, and NPY and CPON in peritubular myoid cells. Our results suggest that the young adult human testis is devoid of monoaminergic nerves but profusely innervated by peptidergic fibers, which may serve as major neuronal regulators for testicular functions at this age.

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“…Various peptidergic effects on testicular steroidogenesis have been reported. Thus, SP reduces the number of luteinizing hormone binding sites in Leydig cells (Kanchev et al, 1995) and inhibits their testosterone production (Angelova et al, 1996). By contrast, GAL potentiates acute gonadotropin or luteinizing hormone-releasing hormone steroidogenic action on rat Leydig cells (Romanelli et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

Suburo

Chiocchio

Soler

et al. 2002

Journal of Andrology

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ABSTRACT:We studied the innervation of the cat testis using a panel of antisera against the following neuronal markers: protein gene product 9.5 (PGP), neuropeptide Y, C-terminal peptide of neuropeptide Y, galanin, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide, and substance P. Immunoreactivity against PGP, a general neuronal label, demonstrated the arrangement of fibers from the superior spermatic nerve (SSN) in the testicular pedicle and the cephalic testicular pole, and those of the inferior spermatic nerve (ISN) along the vas deferens and the inferior testicular ligament. The testicular parenchyma exhibited a very rich innervation, mainly distributed to blood vessels and Leydig cell nests, but also in close association with seminiferous tubules. Numerous peptidergic fibers were present in the SSN and ISN, albeit in different proportions. Thus, VIP-immunoreactive fibers were almost absent in the SSN, but were the most abundant subpopulation of the ISN. The testicular interstitium contained numerous peptidergic fibers, associated with blood vessels, interstitial Leydig cells, and seminiferous tubules. Similar fibers were related to the rete testis. Parenchymatous VIP-immunoreactive nerves disappeared after bilateral vasectomy. Stimulation of the ISN under experimental conditions was associated with an increase of blood flow, and induced a large release of VIP into the spermatic vein. The extensive and selective distribution of nerve fibers within the cat testicular parenchyma supports the importance of spermatic nerves for testicular function. Furthermore, the differences in the fiber composition of the SSN and ISN can be correlated with their opposing effects on testosterone secretion and testicular blood flow.

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Substance P modulating effect on the binding capacity of hamster Leydig cell LH receptors

Cited by 10 publications

References 25 publications

Tachykinins and their possible modulatory role on testicular function: a review

Tachykinins and their possible modulatory role on testicular function: a review

Peptidergic not monoaminergic fibers profusely innervate the young adult human testis

Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

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