Substance P–like immunoreactivity in the lateral cervical nucleus of the owl monkey (<i>Aotus trivirgatus</i>): A comparison with the cat and rat

Broman, Jonas; Blomqvist, Anders

doi:10.1002/cne.902890109

“…Further, in cats and raccoons as well as in ferrets, SP-immunoreactive fibers primarily locate in the ventromedial part of the LCN (Blomqvist et al, 1985b;Giesler and Elde, 1985;Broman and Blomqvist, 1989a;Broman and Pubols, 1993;present study). In monkeys and rats SP-immunoreactive fibers are found scattered throughout the nucleus (Giesler and Elde, 1985;Broman and Blomqvist, 1989a).…”

Section: Comparison With the Cat And Other Speciesmentioning

confidence: 90%

“…The general appearance and location of the lateral cervical nucleus (LCN) in these species are closely similar. In both species substance P (SP)-immunoreactive fibers concentrate in the ventromedial part of the LCN, as do small neurons and GABA-immunoreactive neurons (Broman and Westman, 1988;Broman and Blomqvist, 1989a;Pubols, 1993, 1996). In contrast, GABA-immunoreactive neurons distribute throughout the LCN of monkeys (Broman and Blomqvist, 1989b), as do SP-immunoreactive fibers in the LCN of both monkeys and rats (Giesler and Elde, 1985;Broman and Blomqvist, 1989b).…”

Section: Introductionmentioning

confidence: 98%

Organization of the ferret lateral cervical nucleus and cervicothalamic tract

Zhang

¹

,

Liu

²

,

Broman

³

2002

Somatosensory & Motor Research

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To elucidate the organization of the ferret spinocervicothalamic pathway (SCTP), we examined the lateral cervical nucleus (LCN) and the termination of the cervicothalamic tract (CTY) in this species. In thionin-stained sections, the ferret LCN appeared as an easily delineated column of cells in the dorsolateral funiculus from about mid-C3 to the rostral end of C1, with most cells located in the C1 and C2 segments. In transverse sections, the LCN was elongated along a dorsolateral to ventromedial axis and in the rostral half of C2 and caudal half of C1 continuous with the neck of the dorsal horn. The number of ferret LCN cells was estimated to 2,500-3,700, with an average of 3,340. Substance P-like immunoreactive fibers located preferentially in the ventromedial part of the LCN, whereas serotonin-like immunoreactive fibers were found throughout the nucleus. Anterograde transport of wheat germ agglutinin-horseradish peroxidase conjugate and biotinylated dextran amine demonstrated that the ferret CTT terminates extensively in the peripheral parts of the ventral posterior lateral nucleus. Sparser termination was evident in the ventral posterior inferior nucleus, in the medial nucleus of the posterior complex, and in the medial part of the magnocellular medial geniculate nucleus. Thus, although the LCN is significantly smaller in ferrets than in cats and raccoons, the organization of the LCN and of the cervicothalamic tract is closely similar in the three species. These findings indicate a conserved general organization of the SCTP among carnivores.

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“…The present study, by reporting the presence of a well-developed LCN in bovines and, to some extent, in pigs, indicates that the spinocervicothalamic pathway conveys somatosensory and noxious information from the peripheral receptors to the higher centers of the brain in these species, as well. In the monkey, cat and rat, numerous substance P (SP)-immunoreactive bers were also observed in the LCN (Giesler and Elde, 1985;Broman and Blomqvist, 1989b;Broman and Pubols, 1993). Since SP immunoreactivity is associated with nociceptive function, our further studies will aim to determine the distribution of SP immunoreactivity in the LCN of Artiodactyls as well.…”

Section: Discussionmentioning

confidence: 99%

Anatomical Organization of the Lateral Cervical Nucleus in Artiodactyls

Grandis

¹

,

Gardini

²

,

Tagliavia

³

et al. 2021

Preprint

0

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The presence of the lateral cervical nucleus (LCN) in different mammals, including humans, has been established in a number of anatomical research works. The LCN receives its afferent inputs from the spinocervical tract, and conveys this somatosensory information to the various brain areas, especially the thalamus. In the present study, the organization of the calf and pig LCN was examined through the use of thionine staining and immunohistochemical methods combined with morphometrical analyses. Specifically, the localization of calbindin-D28k (CB-D28k) and neuronal nitric oxide synthase (nNOS) in the LCN was investigated using the immunoperoxidase method. Calf and pig LCN appear as a clearly defined column of gray matter located in the three cranial segments of the cervical spinal cord. Thionine staining shows that polygonal neurons represent the main cell type in both species. The calf and pig LCN contained CB-D28k-immunoreactive (IR) neurons of varying sizes. Large neurons are probably involved in the generation of the cervicothalamic pathway. Small CB-D28k-IR neurons, on the other hand, could act as local interneurons. The immunoreactivity for nNOS was found to be mainly located in thin neuronal processes that could represent the terminal axonal portion of nNOS-IR found in laminae III e IV. This evidence suggests that nitric oxide (NO) could modulate the synaptic activity of the glutamatergic spinocervical tracts. These findings suggest that the LCN of Artiodactyls might play an important role in the transmission of somatosensory information from the spinal cord to the higher centers of the brain.

show abstract

“…The present study, by reporting the presence of a well-developed LCN in bovines and, to some extent, in pigs, indicates that the spinocervicothalamic pathway conveys somatosensory and noxious information from the peripheral receptors to the higher centers of the brain in these species, as well. In the monkey, cat and rat, numerous substance P (SP)-immunoreactive fibers were also observed in the LCN (Giesler and Elde 1985 ; Broman and Blomqvist 1989b ; Broman and Pubols 1993 ). Since SP immunoreactivity is associated with nociceptive function, our further studies will aim to determine the distribution of SP immunoreactivity in the LCN of Artiodactyls as well.…”

Section: Discussionmentioning

confidence: 99%

Anatomical organization of the lateral cervical nucleus in Artiodactyls

Grandis

¹

,

Gardini

²

,

Tagliavia

³

et al. 2021

Vet Res Commun

1

0

View full text Add to dashboard Cite

The presence of the lateral cervical nucleus (LCN) in different mammals, including humans, has been established in a number of anatomical research works. The LCN receives its afferent inputs from the spinocervical tract, and conveys this somatosensory information to the various brain areas, especially the thalamus. In the present study, the organization of the calf and pig LCN was examined through the use of thionine staining and immunohistochemical methods combined with morphometrical analyses. Specifically, the localization of calbindin-D28k (CB-D28k) and neuronal nitric oxide synthase (nNOS) in the LCN was investigated using the immunoperoxidase method. Calf and pig LCN appear as a clearly defined column of gray matter located in the three cranial segments of the cervical spinal cord. Thionine staining shows that polygonal neurons represent the main cell type in both species. The calf and pig LCN contained CB-D28k-immunoreactive (IR) neurons of varying sizes. Large neurons are probably involved in the generation of the cervicothalamic pathway. Small CB-D28k-IR neurons, on the other hand, could act as local interneurons. The immunoreactivity for nNOS was found to be mainly located in thin neuronal processes that could represent the terminal axonal portion of nNOS-IR found in laminae III e IV. This evidence suggests that nitric oxide (NO) could modulate the synaptic activity of the glutamatergic spinocervical tracts. These findings suggest that the LCN of Artiodactyls might play an important role in the transmission of somatosensory information from the spinal cord to the higher centers of the brain.

show abstract

Substance P–like immunoreactivity in the lateral cervical nucleus of the owl monkey (Aotus trivirgatus): A comparison with the cat and rat

Cited by 14 publications

References 34 publications

Organization of the ferret lateral cervical nucleus and cervicothalamic tract

Organization of the ferret lateral cervical nucleus and cervicothalamic tract

Anatomical Organization of the Lateral Cervical Nucleus in Artiodactyls

Anatomical organization of the lateral cervical nucleus in Artiodactyls

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