Substance P levels are decreased in lesional skin of atopic dermatitis

Fantini, Fabrizio; Pincelli, Carlo; Romualdi, Patrizia; Donatini, A.; Giannetti, Alberto

doi:10.1111/j.1600-0625.1992.tb00003.x

Cited by 36 publications

(19 citation statements)

References 23 publications

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“…Indeed, VIP immunoreactivity is markedly increased in atopic dermatitis skin [32] whereas VIP receptor expression on atopic dermatitis mast cells is significantly decreased [33]. In addition, SP levels were described in lower amounts in lesional skin of atopic dermatitis patients compared with controls, whereas SP and CGRP-positive nerve fibres were found to be increased in atopic dermatitis lesional skin [14,32,34] (Table 1).…”

Section: Tachykinins In the Cutaneous Networkmentioning

confidence: 99%

Neuroimmunological findings in allergic skin diseases

Raap

Kapp

2005

Current Opinion in Allergy and Clinical Immunology

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Section: Tachykinins In the Cutaneous Networkmentioning

confidence: 99%

Neuroimmunological findings in allergic skin diseases

Raap

Kapp

2005

Current Opinion in Allergy and Clinical Immunology

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“…Conversely, VIP exhibits immuno-modulatory activity by decreasing the production of pro-inflammatory cytokines [34], [35]. Since VIP expression is upregulated during psoriasis [36], atopic dermatitis [37] (with conflicting results) and skin disorders like aquadynia [38], better knowledge of the mediators leading to VIP release by MCs is of great interest for the understanding of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Merkel Cells as Putative Regulatory Cells in Skin Disorders: An In Vitro Study

et al. 2009

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Merkel cells (MCs) are involved in mechanoreception, but several lines of evidence suggest that they may also participate in skin disorders through the release of neuropeptides and hormones. In addition, MC hyperplasias have been reported in inflammatory skin diseases. However, neither proliferation nor reactions to the epidermal environment have been demonstrated. We established a culture model enriched in swine MCs to analyze their proliferative capability and to discover MC survival factors and modulators of MC neuroendocrine properties. In culture, MCs reacted to bFGF by extending outgrowths. Conversely, neurotrophins failed to induce cell spreading, suggesting that they do not act as a growth factor for MCs. For the first time, we provide evidence of proliferation in culture through Ki-67 immunoreactivity. We also found that MCs reacted to histamine or activation of the proton gated/osmoreceptor TRPV4 by releasing vasoactive intestinal peptide (VIP). Since VIP is involved in many pathophysiological processes, its release suggests a putative regulatory role for MCs in skin disorders. Moreover, in contrast to mechanotransduction, neuropeptide exocytosis was Ca2+-independent, as inhibition of Ca2+ channels or culture in the absence of Ca2+ failed to decrease the amount of VIP released. We conclude that neuropeptide release and neurotransmitter exocytosis may be two distinct pathways that are differentially regulated.

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“…Neuropeptides play an important role in immediate and delayed-type hypersensitivities, as well as in neurogenic inflammation [7], suggesting their possible involvement in the pathophysiology of AD. Increased numbers of nerve fibres containing SP have been found [8, 9]concomitantly with a decrease in cutaneous SP in lesional skin from AD patients [10]. In addition, the skin of AD patients is hyposensitive to intradermal injection of SP [11].…”

Section: Introductionmentioning

confidence: 99%

Role of Substance P in an NC/Nga Mouse Model of Atopic Dermatitis-Like Disease

Ohmura¹,

Tsunenari

Hayashi³

et al. 2004

Int Arch Allergy Immunol

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Background: Atopic dermatitis (AD) can be exacerbated or induced in genetically predisposed individuals by psychological stress, which causes the release of substance P (SP). Therefore, SP may play an etiological role in the mechanisms underlying AD. Methods: Changes in the number of mast cells and SP-containing mast cells in lesional skin, and the serum concentrations of SP and IgE during the development of AD-like disease up to 8 weeks after the start of picryl chloride (PiCl) induction in NC/Nga mice were examined. Results: Clinical signs and symptoms seen in PiCl-treated NC/Nga mice as a model of AD-like disease began with erythema and haemorrhage, followed by oedema, superficial erosion, deep excoriation, scaling and dryness of the skin, as well as retarded growth, and the changes were exacerbated with an increase in the number of PiCl applications. An increase in the number of mast cells and eosinophil infiltration was observed in the lesional skin. The increase in SP-positive mast cells in the dermis in this model was significant from 1 week after the start of induction treatment, compared with intact mice, and SP-positive nerve fibres were observed in the dermis. Conclusion: SP is a crucial mediator of both dermatitis and scratching behaviour in this model.

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Substance P levels are decreased in lesional skin of atopic dermatitis

Cited by 36 publications

References 23 publications

Neuroimmunological findings in allergic skin diseases

Neuroimmunological findings in allergic skin diseases

Merkel Cells as Putative Regulatory Cells in Skin Disorders: An In Vitro Study

Role of Substance P in an NC/Nga Mouse Model of Atopic Dermatitis-Like Disease

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